Degan T J, Fee H J, Ament M E
Am Surg. 1979 Jun;45(6):384-7.
Three patients suffering from colitis associated with cephalexin therapy are reported. All had undergone surgery and had previously suffered severe associated medical problems. Their presenting symptoms included profuse diarrhea, vague abdominal pain, fever and leukocytosis, but all stool cultures were negative. In one case, a pseudomembrane was present; in another only acute inflammatory changes, and in the third patient, no proctosigmoidoscopy or biopsy was done. Cephalosporin therapy was halted and bowel rest as well as intravenous hydration were instituted. All three patients survived. Inasmuch as four cases of colitis associated with cephalosporin therapy have now been treated at UCLA Hospital, the authors believe that this diagnosis should be strongly considered when patients on cephalosporin develop diarrhea.
本文报告了3例与头孢氨苄治疗相关的结肠炎患者。所有患者均接受过手术，且之前患有严重的相关内科疾病。他们的主要症状包括大量腹泻、腹部隐痛、发热和白细胞增多，但所有粪便培养均为阴性。1例患者存在假膜；另1例仅有急性炎症改变，第3例患者未进行直肠乙状结肠镜检查或活检。停用头孢菌素治疗，并采取肠道休息及静脉补液措施。所有3例患者均存活。鉴于加州大学洛杉矶分校医院目前已治疗了4例与头孢菌素治疗相关的结肠炎病例，作者认为，当接受头孢菌素治疗的患者出现腹泻时，应高度考虑这一诊断。
