Fee H J, Ament M E, Holmes E C
Am J Surg. 1977 Feb;133(2):247-8. doi: 10.1016/0002-9610(77)90092-7.
This is the first reported case of cephazolin-associated pseudomembranous colitis. The disease followed a relentless course from its onset to twelve days later when the patient underwent total colectomy for multiple perforations and then died of sepsis. Recent reports indicate that the incidence pseudomembranous colitis is higher than initially appreciated. Early recognition of this entity with confirmation by proctosigmoidoscopy and immediate discontinuance of of antibiotic therapy may reduce the morbidity and mortality of this disease.
这是首例报告的头孢唑林相关性假膜性结肠炎病例。该病从发病到十二天后患者因多处穿孔接受全结肠切除术，随后死于败血症，病程呈进行性发展。近期报告表明，假膜性结肠炎的发病率高于最初的认识。通过直肠乙状结肠镜检查确诊并尽早停用抗生素治疗，可能会降低该病的发病率和死亡率。
