Pseudomembranous colitis associated with cephazolin therapy.

This is the first reported case of cephazolin-associated pseudomembranous colitis. The disease followed a relentless course from its onset to twelve days later when the patient underwent total colectomy for multiple perforations and then died of sepsis. Recent reports indicate that the incidence pseudomembranous colitis is higher than initially appreciated. Early recognition of this entity with confirmation by proctosigmoidoscopy and immediate discontinuance of of antibiotic therapy may reduce the morbidity and mortality of this disease.