Dube B, Misra M K, Nayadamma D
Am Surg. 1979 Jun;45(6):402-6.
Canine shock was experimentally induced by "superior mesenteric artery (SMA) occlusion followed by release:" two hours of occlusion produced reversible shock while four hours of occlusion caused irreversible shock. In both situations, the animals showed coagulopathy but the magnitude of same was more severe in animals with irreversible shock. The nature of coagulation changes was suggestive of intravascular coagulation. Histological changes showed widespread intravascular fibrin thrombi in the liver and the kidney in animals with irreversible shock and only limited local intravascular coagulation in the subcapsular region of the liver in those with reversible shock. The importance of diffuse intravascular coagulation in the irreversibility of shock was also corroborated by the "reversion" of shock by prior heparinization.
通过“肠系膜上动脉（SMA）阻断后再松开”的方法在犬身上实验性诱导休克：阻断两小时产生可逆性休克，而阻断四小时则导致不可逆性休克。在这两种情况下，动物均出现凝血功能障碍，但在不可逆性休克的动物中，其程度更为严重。凝血变化的性质提示血管内凝血。组织学变化显示，不可逆性休克的动物肝脏和肾脏中广泛存在血管内纤维蛋白血栓，而可逆性休克的动物仅在肝脏被膜下区域有局限性的局部血管内凝血。休克不可逆性中弥漫性血管内凝血的重要性也通过预先肝素化使休克“逆转”得到了证实。
