Nagasue N, Iwaki A, Yukaya H, Koyanagi N, Kobayashi M
Surg Gynecol Obstet. 1977 Apr;144(4):519-24.
In eight dogs, acidosis was induced by the infusion of lactic acid into the superior mesenteric artery in a dose of 5.0 to 12.5 millimoles per kilogram during a 30 minute period. Four dogs out of five in which the lowest pH of arterial blood was lower than 7 developed a typical acute disseminated intravascular coagulation, accompanied by a sudden elevation of arterial and portal venous pressure. In these four dogs, refractory shock developed between 0.5 and five hours after lactic acid infusion. The other four without disseminated intravascular coagulation maintained a normal blood pressure and survived until sacrifice six hours after infusion. In two dogs, systemic infusion of 10 millimoles per kilogram was performed in the same interval as the former. Both died from cardiac failure without occurrence of disseminated intravascular coagulation before the infusion was completed. The dogs with disseminated intravascular coagulation revealed a marked deterioration of coagulative system and generalized thrombi in the intestine, liver, lung and kidney. Minimal changes in these parameters were observed in the dogs without disseminated intravascular coagulation. The results suggest that the infusion of lactic acid into the superior mesenteric artery is a convenient model for the production of disseminated intravascular coagulation and resultant shock.
在8只狗中，通过在30分钟内以每千克5.0至12.5毫摩尔的剂量将乳酸注入肠系膜上动脉来诱发酸中毒。在动脉血最低pH低于7的5只狗中，有4只发生了典型的急性弥散性血管内凝血，同时伴有动脉和门静脉压力突然升高。在这4只狗中，乳酸输注后0.5至5小时出现难治性休克。另外4只没有弥散性血管内凝血的狗维持正常血压，并存活至输注后6小时处死。在2只狗中，以与前者相同的间隔进行每千克10毫摩尔的全身输注。两只狗均死于心力衰竭，在输注完成前未发生弥散性血管内凝血。发生弥散性血管内凝血的狗显示凝血系统明显恶化，并且在肠道、肝脏、肺和肾脏中出现广泛性血栓形成。在没有弥散性血管内凝血的狗中观察到这些参数的变化极小。结果表明，将乳酸注入肠系膜上动脉是产生弥散性血管内凝血及所致休克的一种简便模型。
