多发性骨髓瘤中的抗免疫球蛋白
Anit-immunoglobulins in multiple myeloma.
作者信息
Abdou N I, Abdou N L
出版信息
Clin Exp Immunol. 1972 May;11(1):57-65.
Abstract
Human myeloma cells isolated from bone marrow aspirates by sucrose density gradients and cultured were shown to undergo proliferation and increased DNA synthesis upon incubation with anti-immunoglobulin (anti-Ig) antisera directed against the immunoglobulin that these cells carry or secrete. A circulating anti-Ig could be detected in the sera of the majority of these patients. In a γ-globulin-free medium, the isolated anti-Ig could stimulate the patient's own plasma cells to undergo proliferation . The possible role of circulating anti-Ig in the continued proliferation of a specific clone of bone marrow cells is discussed.
摘要
通过蔗糖密度梯度从骨髓抽吸物中分离并培养的人骨髓瘤细胞，在与针对这些细胞携带或分泌的免疫球蛋白的抗免疫球蛋白（抗Ig）抗血清孵育后，显示出增殖并增加了DNA合成。在这些患者的大多数血清中可检测到循环抗Ig。在无γ球蛋白的培养基中，分离出的抗Ig可刺激患者自身的浆细胞增殖。本文讨论了循环抗Ig在骨髓细胞特定克隆持续增殖中的可能作用。
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引用本文的文献
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本文引用的文献
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The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.蛋白质在经单宁酸处理的红细胞上的吸附以及随后抗蛋白质血清引起的血细胞凝集。
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Binding of rabbit antibodies to a mouse myeloma protein by the myeloma cells in vitro.体外培养的骨髓瘤细胞使兔抗体与小鼠骨髓瘤蛋白结合。
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Anti-nucleic acid specificites of mouse myeloma immunoglobulins.小鼠骨髓瘤免疫球蛋白的抗核酸特异性
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