多发性骨髓瘤中的抗免疫球蛋白
Anit-immunoglobulins in multiple myeloma.
作者信息
Abdou N I, Abdou N L
出版信息
Clin Exp Immunol. 1972 May;11(1):57-65.
Abstract
Human myeloma cells isolated from bone marrow aspirates by sucrose density gradients and cultured were shown to undergo proliferation and increased DNA synthesis upon incubation with anti-immunoglobulin (anti-Ig) antisera directed against the immunoglobulin that these cells carry or secrete. A circulating anti-Ig could be detected in the sera of the majority of these patients. In a γ-globulin-free medium, the isolated anti-Ig could stimulate the patient's own plasma cells to undergo proliferation . The possible role of circulating anti-Ig in the continued proliferation of a specific clone of bone marrow cells is discussed.
摘要
通过蔗糖密度梯度从骨髓抽吸物中分离并培养的人骨髓瘤细胞，在与针对这些细胞携带或分泌的免疫球蛋白的抗免疫球蛋白（抗Ig）抗血清孵育后，显示出增殖并增加了DNA合成。在这些患者的大多数血清中可检测到循环抗Ig。在无γ球蛋白的培养基中，分离出的抗Ig可刺激患者自身的浆细胞增殖。本文讨论了循环抗Ig在骨髓细胞特定克隆持续增殖中的可能作用。
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引用本文的文献
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