Ahuja S, Lewis S M, Szur L
J Clin Pathol. 1972 Jun;25(6):467-72. doi: 10.1136/jcp.25.6.467.
The value of surface counting with (51)Cr-labelled red cells in predicting response to splenectomy in haemolytic anaemia has been analysed in 18 cases. The cases included six patients with congenital haemolytic anaemias, four with primary autoimmune haemolytic anaemias, and eight patients with secondary haemolytic anaemias (four with a positive antiglobulin test). All patients showed evidence of splenic accumulation of labelled cells and in 16 of the cases this was confined to the spleen. Improvement followed splenectomy in 17 of the cases although there was no close correlation between the magnitude of accumulation of radioactivity as measured by excess counts and the degree of response. The reasons for these discrepancies are discussed, The only patient who completely failed to respond to splenectomy had a sideroblastic element to the anaemia. It has been concluded that surface counting is of value in selecting patients for splenectomy but should not be depended upon without reference to other clinical and haematological factors, which are likely to influence the prognosis.
对18例溶血性贫血患者进行了分析，以探讨用（51）铬标记红细胞进行体表计数在预测脾切除反应方面的价值。这些病例包括6例先天性溶血性贫血患者、4例原发性自身免疫性溶血性贫血患者和8例继发性溶血性贫血患者（4例抗球蛋白试验阳性）。所有患者均显示标记细胞在脾脏中有积聚，16例患者的这种积聚局限于脾脏。17例患者脾切除后病情改善，尽管通过过量计数测量的放射性积聚程度与反应程度之间没有密切相关性。讨论了这些差异的原因。唯一对脾切除完全无反应的患者贫血中存在铁粒幼细胞成分。得出的结论是，体表计数在选择脾切除患者方面有价值，但不应在不参考其他可能影响预后的临床和血液学因素的情况下依赖它。
