Ferrant A, Cauwe F, Michaux J L, Beckers C, Verwilghen R, Sokal G
Br J Haematol. 1982 Apr;50(4):591-8. doi: 10.1111/j.1365-2141.1982.tb01959.x.
Red cell survival, surface counting indices, the splenic and hepatic contribution to red cell destruction and the rate of splenic and hepatic red cell destruction were measured in 29 patients. Splenectomy was performed in 14. No correlation could be found between the splenic excess count index and both the amount and rate of red cell destruction in the spleen, but the rate of splenic and hepatic red cell destruction was related to the rate of disappearance of red cells from the circulation. The mean fractions of red cell destruction in spleen and liver were 46.1% +/- 20.5 (SD) and 11.7% +/- 4.2 (SD) respectively. After splenectomy, the haematocrit returned to normal in all patients despite fractions of red cell destruction in the spleen not exceeding 60%. Although the measurements of the splenic red cell destruction rate and of the fraction of red cell destruction in the spleen provide more precise information on the role of the spleen in red cell destruction, their prognostic value in patients who underwent splenectomy was not obvious.
对29例患者测量了红细胞生存期、表面计数指数、脾脏和肝脏对红细胞破坏的贡献以及脾脏和肝脏红细胞破坏率。14例患者接受了脾切除术。脾脏过量计数指数与脾脏中红细胞破坏的量和速率之间均未发现相关性，但脾脏和肝脏红细胞破坏率与红细胞从循环中消失的速率相关。脾脏和肝脏中红细胞破坏的平均比例分别为46.1%±20.5（标准差）和11.7%±4.2（标准差）。脾切除术后，所有患者的血细胞比容均恢复正常，尽管脾脏中红细胞破坏比例不超过60%。虽然脾脏红细胞破坏率和脾脏中红细胞破坏比例的测量为脾脏在红细胞破坏中的作用提供了更精确的信息，但其对接受脾切除术患者的预后价值并不明显。
