Molteni A, Bahu R M, Battifora H A, Fors E M, Reddy J K, Rao M S, Scarpelli D G
Ann Clin Lab Sci. 1979 Mar-Apr;9(2):103-8.
Estradiol (E2) binding activity was studied in several normal tissues and neoplasias of humans and experimental animals. Positive E2 binding was seen in 37 percent of breast primary malignancies, 50 percent of breast cancer metastasis to other organs, and 55 percent of breast cancer metastasis to lymph nodes. Two other tumors, renal cell carcinomas and thyroid adenocarcinomas, also had a high percent of E2 binding activity. No difference was evident histologically between the tumors which were positive and those which were negative. Elevated E2 binding activity was seen in normal liver and pancreas of rats and mice as well as in an experimentally induced acinar pancreatic carcinoma of the rats. These preliminary results indicate that the measurement of estradiol receptors should be extended to other neoplasias than breast cancer, and it may give some indication about the evolution and the hormonal controls of the tumors themselves.
在人类和实验动物的几种正常组织及肿瘤中研究了雌二醇（E2）结合活性。在37%的原发性乳腺恶性肿瘤、50%转移至其他器官的乳腺癌以及55%转移至淋巴结的乳腺癌中可见E2结合阳性。另外两种肿瘤，肾细胞癌和甲状腺腺癌，也有较高比例的E2结合活性。E2结合阳性和阴性的肿瘤在组织学上无明显差异。在大鼠和小鼠的正常肝脏和胰腺以及大鼠实验诱导的胰腺腺泡癌中可见E2结合活性升高。这些初步结果表明，雌二醇受体的检测应扩展至乳腺癌以外的其他肿瘤，并且这可能为肿瘤自身的演变和激素调控提供一些线索。
