Møller R, Reymann F, Hou-Jensen K
Arch Dermatol. 1979 Jun;115(6):703-5. doi: 10.1001/archderm.1979.04010060011017.
Two hundred eleven patients in whom squamous cell carcinoma (SCC) of the skin had been diagnosed between 1950 and 1959 were followed up from Jan 1, 1976, to establish the incidence of metastases. A systemic study was carried out through follow-up examinations and tracing through population registers. We found 3.3% metastases in 153 patients with skin SCC and 11% metastases in 55 patients with labial SCC. Three patients with genital SCC were free of metastases. These results and the available literature on patients with SCC of osteomyelitic foci and scars from burns or x-ray treatment indicate that sharp distinctions must be made among three groups of SCC; mucocutaneous, primary cutaneous, and cutaneous SCC secondary to inflammatory and degenerative processes. The incidence of metastases in the three groups is approximately 11%, 3%, and 10% to 30%, respectively. Percentages found are important to dermatology clinics because skin SCC should be considered a malignant tumor with a higher incidence of metastases than previously assumed.
对1950年至1959年间诊断为皮肤鳞状细胞癌（SCC）的211例患者进行随访，从1976年1月1日开始，以确定转移发生率。通过随访检查和人口登记进行系统研究。我们发现153例皮肤SCC患者中有3.3%发生转移，55例唇部SCC患者中有11%发生转移。3例生殖器SCC患者无转移。这些结果以及关于骨髓炎病灶和烧伤或X线治疗瘢痕的SCC患者的现有文献表明，必须在三组SCC之间做出明确区分；粘膜皮肤型、原发性皮肤型和继发于炎症和退行性病变的皮肤型SCC。三组的转移发生率分别约为11%、3%和10%至30%。所发现的百分比对皮肤科诊所很重要，因为皮肤SCC应被视为一种转移发生率高于先前假设的恶性肿瘤。
