源自光化性角化病的转移性皮肤鳞状细胞癌。

Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis.

作者信息

Dinehart S M, Nelson-Adesokan P, Cockerell C, Russell S, Brown R

机构信息

Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, USA.

出版信息

Cancer. 1997 Mar 1;79(5):920-3. doi: 10.1002/(sici)1097-0142(19970301)79:5<920::aid-cncr8>3.0.co;2-f.

DOI:10.1002/(sici)1097-0142(19970301)79:5<920::aid-cncr8>3.0.co;2-f

PMID:9041154

Abstract

BACKGROUND

Squamous cell carcinoma (SCC) with histologically contiguous actinic keratosis has long been thought of as a tumor with minimal risk for metastasis. The objective of this study was to determine if contiguous actinic keratosis is present in the original tumors of metastatic cutaneous SCC and to describe the histologic features of these tumors.

METHODS

The primary lesions of 22 patients with metastatic cutaneous SCC were examined using light microscopy.

RESULTS

Contiguous actinic keratosis was present histologically in 44% of the original lesions of cutaneous SCC that metastasized. The average tumor thickness was 6.6 mm. Greater than 66% of the tumors were well or moderately differentiated. The skin adjacent to the tumors showed solar degeneration in almost all instances.

CONCLUSIONS

The histologic presence of contiguous actinic keratosis is not a useful predictor of the metastatic behavior of cutaneous SCC. Increased tumor thickness and depth of invasion are the most consistent histopathologic features of cutaneous SCC that metastasize.

摘要