Shmunes E
Arch Dermatol. 1979 Jul;115(7):882-3.
A patient with gradually increasing hair loss was undergoing long-term renal dialysis. Questioning revealed that her supplemental vitamin program had contained vitamin A only to that extent it was included in a portion of multivitamins taken in conventional amounts for approximately three years. Her serum vitamin A level was 140 micrograms/dL (a normal level is 20 to 80 micrograms/dL). Reports have indicated that chronic renal disease results in a state of relative hypervitaminosis A. This is compounded in renal dialysis by failure to remove vitamin A. The administration of low-dose supplemental vitamin A preparations in this select population is discussed with respect to current concepts of vitamin A metabolism in renal disease.
一名脱发逐渐加重的患者正在接受长期肾脏透析。询问得知，她的补充维生素方案仅包含常规剂量多种维生素中所含的维生素A，这种情况持续了约三年。她的血清维生素A水平为140微克/分升（正常水平为20至80微克/分升）。有报告指出，慢性肾病会导致相对维生素A过多症状态。在肾脏透析过程中，由于无法清除维生素A，这种情况会更加严重。本文结合当前关于肾病中维生素A代谢的概念，讨论了在这一特定人群中给予低剂量补充维生素A制剂的问题。
