组织相容性抗原对小鼠淋巴细胞迁移的影响。
The effect of histocompatibility antigens on lymphocyte migration in the mouse.
作者信息
Zatz M M, Gingrich R, Lance E M
出版信息
Immunology. 1972 Nov;23(5):665-75.
Migration patterns of Cr-labelled murine lymph node cells were studied in syngeneic, allogeneic, semi-allogeneic and congenic strain combinations. In certain allogeneic and semi-allogeneic combinations with strong H-2 histoincompatibility, reduced migration of a donor population representing recirculating lymphocytes into recipient lymph nodes was observed. This phenomen could be reproduced in congenic strains differing only at the H-2 locus, and was not seen in congenic strains differing at the Ly-A, Ly-B, RZ, M, or θ loci. The kinetics of reduced lymphocyte homing to allogeneic lymph nodes and the role of host and donor recognition were investigated. These studies are discussed in relation to possible mechanisms of action, and relevance to factors regulating lymphocyte recirculation.
研究了铬标记的小鼠淋巴结细胞在同基因、异基因、半异基因和同类系菌株组合中的迁移模式。在某些具有强烈H-2组织不相容性的异基因和半异基因组合中，观察到代表再循环淋巴细胞的供体群体向受体淋巴结的迁移减少。这种现象可以在仅在H-2位点不同的同类系菌株中重现，而在Ly-A、Ly-B、RZ、M或θ位点不同的同类系菌株中未观察到。研究了淋巴细胞归巢至异基因淋巴结减少的动力学以及宿主和供体识别的作用。讨论了这些研究与可能的作用机制以及与调节淋巴细胞再循环的因素的相关性。
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