胸腺依赖和非胸腺依赖群体：起源、迁移模式和寿命。
Thymus-dependent and thymus-independent populations: origin, migratory patterns and lifespan.
作者信息
Parrott D M, De Sousa M
出版信息
Clin Exp Immunol. 1971 May;8(5):663-84.
Abstract
It is now accepted that there are present within the peripheral lymphoid tissues of the mammal, lymphocytes which differ in their origin, migratory patterns and lifespan; two major groups have so far been defined, one of thymus-dependent or thymus-derived lymphocytes and another of thymus-independent or bone-marrow derived lymphocytes. These cells which are morphologically indistinguishable when free floating in the blood or lymph nevertheless segregate from one another into clearly defined compartments whilst resident in or passing through the lymph nodes, spleen or Peyer's patches. The purpose of this article is to summarize some of the experimental evidence for this segregation and to discuss its physiological and immunological implications. It is not intended to be an extensive review of the literature.
摘要
现在已经公认，在哺乳动物的外周淋巴组织中存在着起源、迁移模式和寿命不同的淋巴细胞；到目前为止，已经确定了两大类，一类是胸腺依赖性或胸腺衍生的淋巴细胞，另一类是胸腺非依赖性或骨髓衍生的淋巴细胞。这些细胞在血液或淋巴中自由漂浮时在形态上无法区分，但在驻留在或穿过淋巴结、脾脏或派尔集合淋巴结时会彼此分离到明确界定的区域。本文的目的是总结一些关于这种分离的实验证据，并讨论其生理和免疫学意义。本文并非对文献的全面综述。
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