血吸虫病异源免疫的研究。5. 绵羊中的异源血吸虫免疫。
Studies on heterologous immunity in schistosomiasis. 5. Heterologous schistosome immunity in sheep.
作者信息
Preston J M, Nelson G S, Saeed A A
出版信息
Bull World Health Organ. 1972;47(5):587-90.
Previous studies have shown that when cattle are exposed to cercariae of Schistosoma mansoni they develop considerable resistance to subsequent challenge with S. mattheei. The present study showed that when sheep are immunized with S. mansoni cercariae they too develop a marked resistance to subsequent challenge with S. mattheei. A small proportion of the immunizing cercariae reached maturity and a few viable S. mansoni eggs were found in the faeces of the sheep. The results of this experiment provide further evidence that heterologous immunity may be of significance in limiting the severity of schistosomiasis in both man and domestic animals in areas where animal and human schistosomes occur together.
先前的研究表明，当牛接触曼氏血吸虫尾蚴时，它们会对随后感染马修氏血吸虫产生相当大的抵抗力。本研究表明，当绵羊用曼氏血吸虫尾蚴免疫时，它们同样会对随后感染马修氏血吸虫产生显著的抵抗力。一小部分免疫尾蚴发育成熟，并且在绵羊粪便中发现了一些活的曼氏血吸虫卵。该实验结果进一步证明，在动物血吸虫和人类血吸虫共同存在的地区，异源免疫对于限制人和家畜血吸虫病的严重程度可能具有重要意义。
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