Bickle Q D, Taylor M G, James E R, Nelson G S, Hussein M F, Andrews B J, Dobinson A R, Marshall T F
Parasitology. 1979 Apr;78(2):185-93. doi: 10.1017/s0031182000049234.
This paper describes further characteristics of the immunization of sheep against schistosomes using live, irradiation schistosomula. Sheep immunized with a non-virulent strain of Schistosoma mattheei were protected against a more virulent strain of the same species for over a year. As there was no evidence that the irradiated parasites were able to persist this long, it was concluded that the vaccine had induced a sterile resistance. Heterologous vaccination, using irradiated S. mattheei schistosomula to immunize against S. bovis or irradiated S. mansoni schistosomula to immunize against S. mattheei, failed to induce any protection.
本文描述了使用活的、经辐照的血吸虫童虫对绵羊进行血吸虫免疫的进一步特征。用无毒株的马氏血吸虫免疫的绵羊，可抵御同一物种更强毒株的感染长达一年以上。由于没有证据表明经辐照的寄生虫能够存活如此之久，因此得出结论，该疫苗诱导了无菌免疫力。使用经辐照的马氏血吸虫童虫对牛血吸虫进行异源免疫，或使用经辐照的曼氏血吸虫童虫对马氏血吸虫进行异源免疫，均未能诱导出任何保护作用。
