Bergmann V
Arch Exp Veterinarmed. 1979 Jan;33(1):13-20.
Sings of myopathy were recorded by means of electron microscopy from the skeletal muscles of 20 broiler chickens, aged five and six weeks and suffering from spontaneous nutritional encephalomalacia. Focal deposits of osmiophilic, granular or amorphous matter, intermixed also with membrane fragments and condensed to homogenous osmiophilic bodies, were found quite often in the sarcoplasm. Those deposits were interpreted as lipoproteid complexes (pigmentation due to vitamin E deficit). Also observed were degenerative disorders of compensatory reactions of membraneous fibre organelles (sarcoplasmic reticulum, mitochondria) as well as decomposition of myofibrils and fibre hyalinization. Fibre regeneration and vascular damage occurred less often. Pathogenetically, the changes are interpreted particularly with regard to a membrane-stabilising anti-oxidant action of vitamin E and compared to the selenium-dependent myopathies of ruminants from which primary myofibrillar damage was recordable but no pigment accumulation.
通过电子显微镜对20只5至6周龄患有自发性营养性脑软化症的肉鸡骨骼肌进行检查，记录到了肌病迹象。在肌浆中经常发现嗜锇性、颗粒状或无定形物质的局灶性沉积，这些物质还与膜碎片混合，并浓缩成均匀的嗜锇性小体。这些沉积物被解释为脂蛋白复合物（因维生素E缺乏导致的色素沉着）。还观察到膜性纤维细胞器（肌浆网、线粒体）代偿反应的退行性病变以及肌原纤维的分解和纤维玻璃样变性。纤维再生和血管损伤较少发生。从发病机制来看，这些变化尤其与维生素E稳定膜的抗氧化作用有关，并与反刍动物的硒依赖性肌病进行了比较，在反刍动物的硒依赖性肌病中可记录到原发性肌原纤维损伤，但没有色素积累。
