细胞外pH值选择性调节蛙有髓神经钠通道失活后的恢复过程。
Extracellular pH selectively modulates recovery from sodium inactivation in frog myelinated nerve.
作者信息
Courtney K R
出版信息
Biophys J. 1979 Nov;28(2):363-8. doi: 10.1016/S0006-3495(79)85183-8.
Abstract
The Hodgkin-Huxley kinetic parameters, alpha h and beta h, which govern the rate of recovery from and development of sodium channel inactivation, respectively, have been measured as a function of membrane potential and external pH using a three-pulse protocol. alpha h but not beta h is substantially accelerated by reducing external pH from 7.4 to 6.4. The alpha h vs. voltage curve appears to be selectively shifted in the depolarizing direction by approximately 12 mV for this pH change, giving an apparent, h infinity curve shift of approximately 6 mV in the same direction (less inactivation).
摘要
霍奇金-赫胥黎动力学参数αh和βh分别控制钠通道失活的恢复速率和发展速率，使用三脉冲协议测量了它们作为膜电位和外部pH值的函数。通过将外部pH值从7.4降低到6.4，αh而非βh显著加速。对于这种pH变化，αh与电压曲线似乎在去极化方向上选择性地偏移了约12 mV，在相同方向上（失活减少）表观h∞曲线偏移了约6 mV。
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