Hiratzka L F, Goeken J A, White R A, Wright C B
Arch Surg. 1979 Jun;114(6):698-702. doi: 10.1001/archsurg.1979.01370300052007.
The replamineform process allows fabrication of microporous prostheses with control of both pore diameter and structural geometry by means of a variety for biomaterials. Tubular prostheses 3 cm long, 6 mm inside diameter, and 1 mm wall thickness were made of Silastic or Bioelectric Polyurethane (BEP) with use of a template of the echinoderm Heterocentrotus mammillatus. Pore diameter of the prosthesis wall was 18 to 25 mu. Light and scanning-electron microscopy of grafts removed between 1 and 32 weeks demonstrated that organization and endothelialization of neointima were similar for both polymers, being complete by 4 to 8 weeks. However, the character of prosthesis wall ingrowth was strikingly different: the microporous lattice of BEP was completely ingrown early, but was apparently fragmented by continued granulomatous inflammation by 32 weeks, while Silastic generated minimal inflammatory response and slower fibrous tissue and capillary ingrowth. Thus, with Silastic and BEP, similarities in neointima organization appeared independent of distinct differences in wall ingrowth. The replamineform process is a unique means of studying surface healing and wall ingrowth of different biomaterials as microporous vascular prostheses in a controlled fashion.
复制模塑工艺能够通过多种生物材料制造出微孔假体，同时控制孔径和结构几何形状。使用海胆（Heterocentrotus mammillatus）模板，制作了长度为3厘米、内径为6毫米、壁厚为1毫米的管状假体，材料为硅橡胶或生物电聚氨酯（BEP）。假体壁的孔径为18至25微米。对在1至32周之间取出的移植物进行光学显微镜和扫描电子显微镜检查显示，两种聚合物的新内膜组织形成和内皮化情况相似，在4至8周时完成。然而，假体壁向内生长的特征却显著不同：BEP的微孔晶格早期完全向内生长，但到32周时明显因持续的肉芽肿性炎症而破碎，而硅橡胶产生的炎症反应最小，纤维组织和毛细血管向内生长较慢。因此，对于硅橡胶和BEP，新内膜组织形成的相似性似乎与壁向内生长的明显差异无关。复制模塑工艺是一种以可控方式研究不同生物材料作为微孔血管假体的表面愈合和壁向内生长的独特方法。
