Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heart.

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作者信息

Ward W F, Chua B L, Li J B, Morgan H E, Mortimore G E

出版信息

Biochem Biophys Res Commun. 1979 Mar 15;87(1):92-8. doi: 10.1016/0006-291x(79)91651-6.

DOI:10.1016/0006-291x(79)91651-6

PMID:454413

Abstract

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Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heart.

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Effects of leupeptin and pepstatin on protein turnover in adult rat hepatocytes in primary culture.亮抑酶肽和胃蛋白酶抑制剂对原代培养成年大鼠肝细胞蛋白质周转的影响。

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Protein degradation in rat liver cells.大鼠肝细胞中的蛋白质降解

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Participation of lysosomes in basal proteolysis in perfused rat liver. Discrepancy between leupeptin-induced lysosomal enlargement and inhibition of proteolysis.溶酶体参与灌注大鼠肝脏的基础蛋白水解作用。亮肽素诱导的溶酶体增大与蛋白水解抑制之间的差异。

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Pepstatin- and leupeptin-loaded liposomes: a tool in protein breakdown studies.载有胃蛋白酶抑制剂和亮抑酶肽的脂质体：蛋白质分解研究的一种工具。

Acta Biol Med Ger. 1977;36(11-12):1829-31.

Inhibition of 125I-asialofetuin catabolism by leupeptin in the perfused rat liver and in vivo.

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Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes.氨基酸、氨和亮抑蛋白酶肽对分离的大鼠肝细胞中蛋白质合成与降解的影响。

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[Inhibition of extracellular yeast proteinases by pepstatin A and leupeptin in the plate test].[平板试验中胃蛋白酶抑制剂A和亮抑酶肽对细胞外酵母蛋白酶的抑制作用]

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Delayed degeneration of dystrophic and normal muscle cell cultures treated with pepstatin, leupeptin, and antipain.用胃蛋白酶抑制剂、亮抑蛋白酶肽和抗蛋白酶处理的营养不良性和正常肌肉细胞培养物的延迟变性。

Exp Neurol. 1976 Mar;50(3):649-57. doi: 10.1016/0014-4886(76)90034-0.

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Biochem J. 1980 Oct 15;192(1):311-20. doi: 10.1042/bj1920311.

Intracellular disruption of rat heart lysosomes by leucine methyl ester: effects on protein degradation.亮氨酸甲酯对大鼠心脏溶酶体的细胞内破坏作用：对蛋白质降解的影响。

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Effects of leupeptin on endocytosis and membrane recycling in rat visceral yolk-sac endoderm.亮抑酶肽对大鼠内脏卵黄囊内胚层内吞作用及膜循环的影响。

Histochemistry. 1986;85(2):169-75. doi: 10.1007/BF00491765.

The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism.钙离子或肌肉损伤对肌肉中蛋白质降解的激活不涉及溶酶体机制。

Biochem J. 1986 Aug 1;237(3):859-64. doi: 10.1042/bj2370859.

Lysosomal protein degradation in experimental hyperphenylalaninaemia.实验性高苯丙氨酸血症中的溶酶体蛋白降解

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Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts.抑制剂研究表明，活性组织蛋白酶L可能对其在培养的成纤维细胞中的自身加工过程至关重要。

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Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids.胰高血糖素诱导的大鼠肝脏自噬和蛋白水解：通过细胞内氨基酸的选择性剥夺介导

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