抗氧化剂、类固醇及其他化合物对大鼠不同组织中苯并(a)芘3-羟化酶活性的差异影响。
Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
作者信息
Rahimtula A D, Zachariah P K, O'Brien P J
出版信息
Br J Cancer. 1979 Jul;40(1):105-12. doi: 10.1038/bjc.1979.146.
Abstract
Antioxidants were found to inhibit the mixed-function oxidation of benzo(a)pyrene in several tissues of untreated and 3-methylcholanthrene-pretreated rats. The enzyme systems in the liver, kidney and stomach were much more susceptible to inhibition than those in the lung, adrenal, colon and small intestine. In all tissues except the stomach it was found that 3-methylcholanthrene pretreatment led to a decrease in inhibition of benzo(a)pyrene 3-hydroxylase activity. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites. Of the various steroids tested, only 17 beta-oestradiol and oestrone were significantly inhibitory in most tissues. Cholesterol was found to increase benzo(a)pyrene 3-hydroxylase activity in the gastrointestinal tract.
摘要
研究发现，抗氧化剂可抑制未处理及经3-甲基胆蒽预处理大鼠多个组织中苯并(a)芘的混合功能氧化。肝脏、肾脏和胃中的酶系统比肺、肾上腺、结肠和小肠中的酶系统更易受到抑制。除胃外，在所有组织中均发现，3-甲基胆蒽预处理导致苯并(a)芘3-羟化酶活性的抑制作用降低。有人提出，抗氧化剂通过抑制致癌代谢物的形成发挥抗癌保护作用。在所测试的各种类固醇中，只有17β-雌二醇和雌酮在大多数组织中具有显著抑制作用。发现胆固醇可增加胃肠道中苯并(a)芘3-羟化酶的活性。
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本文引用的文献
1
EFFECTS OF PHENOTHIAZINES ON PROTECTIVE SYSTEMS AGAINST POLYCYCLIC HYDROCARBONS.吩噻嗪对多环烃防护系统的影响
Cancer Res. 1965 Apr;25:365-70.
2
Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States.日本移民研究。一、美国日本人的癌症及其他疾病死亡率。
J Natl Cancer Inst. 1968 Jan;40(1):43-68.
3
Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity.对可能与癌症相关的肠道多环烃羟化酶的研究。饮食对苯并芘羟化酶活性的影响。
Cancer. 1971 Jul;28(1):99-102. doi: 10.1002/1097-0142(197107)28:1<99::aid-cncr2820280118>3.0.co;2-m.
4
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.酚类抗氧化剂和乙氧喹对多环烃致癌和毒性作用的抑制
J Natl Cancer Inst. 1972 May;48(5):1425-30.
5
Bacteria and the etiology of colonic cancer.细菌与结肠癌的病因学
Cancer. 1974 Sep;34(3):suppl:815-8. doi: 10.1002/1097-0142(197409)34:3+<815::aid-cncr2820340705>3.0.co;2-6.
6
Arene oxides: a new aspect of drug metabolism.芳烃氧化物：药物代谢的一个新方面。
Science. 1974 Aug 16;185(4151):573-82. doi: 10.1126/science.185.4151.573.
7
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by several sulfur-containing compounds.几种含硫化合物对多环烃致癌和毒性作用的抑制
J Natl Cancer Inst. 1974 May;52(5):1583-7. doi: 10.1093/jnci/52.5.1583.
8
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Biochem Biophys Res Commun. 1973 Oct 15;54(4):1241-6. doi: 10.1016/0006-291x(73)91120-0.
9
Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxyanisole.丁基羟基茴香醚对化学致癌物诱导的肺肿瘤形成的抑制作用。
J Natl Cancer Inst. 1973 Jun;50(6):1541-4. doi: 10.1093/jnci/50.6.1541.
10
Properties of benzpyrene hydroxylase in the liver, intestinal mucosa and adrenal of untreated and 3-methylcholanthrene-treated rats.
J Pharmacol Exp Ther. 1973 Jun;185(3):676-85.
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