离体大鼠肝细胞核及核膜中苯并(a)芘羟化酶的诱导剂和抑制剂对苯并(a)芘与DNA结合的影响。 - Suppr | 超能文献

Effects of inducers and inhibitors of the benzo(a)pyrene hydroxylase of isolated rat liver nuclei and nuclear envelopes on the binding of benzo(a)pyrene to DNA.

作者信息

Alexandrov K

出版信息

Eur J Cancer (1965). 1977 Aug;13(8):847-53. doi: 10.1016/0014-2964(77)90140-2.

DOI:10.1016/0014-2964(77)90140-2

Abstract

摘要

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Effects of inducers and inhibitors of the benzo(a)pyrene hydroxylase of isolated rat liver nuclei and nuclear envelopes on the binding of benzo(a)pyrene to DNA.离体大鼠肝细胞核及核膜中苯并(a)芘羟化酶的诱导剂和抑制剂对苯并(a)芘与DNA结合的影响。

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Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.在分离的大鼠肝微粒体和细胞核中形成与DNA结合的苯并(a)芘代谢产物。

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Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity.通过选择性诱导微粒体和细胞核芳烃羟化酶活性对致癌物苯并(a)芘在体内与大鼠肝脏DNA结合的调节作用。

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Influence of inducers and inhibitors of mixed-function oxidasts on benzo(a)pyrene binding to the DNA of rat liver nuclei.混合功能氧化酶诱导剂和抑制剂对苯并(a)芘与大鼠肝细胞核DNA结合的影响。

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Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity.椭圆玫瑰树碱作为芳烃羟化酶的强效抑制剂：它们与微粒体细胞色素P450的结合及对苯并(a)芘致突变性的保护作用。

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Effect of selected induction of microsomal and nuclear aryl hydrocarbon monooxygenase and epoxide hydrolase as well as cytoplasmic glutathione S-epoxide transferase on the covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo.微粒体和细胞核芳烃单加氧酶、环氧化物水解酶以及细胞质谷胱甘肽S-环氧化物转移酶的特定诱导对致癌物苯并(a)芘在体内与大鼠肝脏DNA共价结合的影响。

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Comparison of the metabolism of benzo[alpha]pyrene and binding to DNA caused by rat liver nuclei and microsomes.大鼠肝细胞核与微粒体对苯并[a]芘的代谢及与DNA结合的比较。

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[Role of inhibitor analysis in the complex assessment of the content and activity of microsomal benzopyrene hydroxylases].[抑制剂分析在微粒体苯并芘羟化酶含量与活性综合评估中的作用]

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Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase-catalyzed formation of active oxygen.纯化大鼠肝细胞核中芳烃的代谢激活：酶活性的诱导以及在有无单加氧酶催化活性氧形成情况下与DNA的结合。

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Effects of estrogens on aryl hydrocarbon hydroxylase mediated binding of benzo(a) pyrene metabolites to DNA in vitro.雌激素对体外芳烃羟化酶介导的苯并(a)芘代谢产物与DNA结合的影响。

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