Lynne-Davies G, Brown J
Can Med Assoc J. 1974 Jun 22;110(12):1377-9.
The cases are presented of two siblings with multiple cutaneous tumours associated with adenomatous polyps of the colon and bony abnormalities. In one patient an adenocarcinoma of the colon supervened, and there was a history of adenocarcinoma of the colon without the presence of other abnormalities in a third sibling. Clinically the sebaceous tumours resembled sebaceous hyperplasia, but histologically they exhibited features of sebaceous adenoma.The association of a variety of multiple soft tissue tumours, particularly epidermal cysts, with polyposis of the colon and bony abnormalities is well recognized. However, multiple solid sebaceous tumours have not been reported previously as a feature of this syndrome. They should in future alert the physician to the possible presence of multiple polyposis of the colon in affected individuals and immediate relatives.
本文报告了两例患有多种皮肤肿瘤的兄弟姐妹，这些肿瘤与结肠腺瘤性息肉及骨骼异常相关。其中一名患者后来发生了结肠癌，第三名兄弟姐妹有结肠癌病史，但无其他异常。临床上，皮脂腺肿瘤类似皮脂腺增生，但组织学上表现为皮脂腺瘤的特征。多种软组织肿瘤，特别是表皮囊肿，与结肠息肉病及骨骼异常的关联已得到充分认识。然而，此前尚未有报道称多发性实性皮脂腺肿瘤是该综合征的特征。未来，它们应提醒医生注意受影响个体及其直系亲属可能存在结肠多发性息肉病。
