Ahrén B, Ericsson M, Hedner P, Ingemansson S, Westgren U
J Clin Endocrinol Metab. 1978 Nov;47(5):1156-9. doi: 10.1210/jcem-47-5-1156.
The effect of somatostatin on thyroid hormone secretion stimulated by TSH in man was studied. The injection of TSH into a thyroid artery during surgery was followed by an increase in the serum concentration of iodothyronines in the corresponding thyroid vein. This increase was significantly lower (p less than 0.02) when somatostatin was given as a bolus injection into a peripheral vein 5 min prior to the administration of TSH, and followed by a continuous infusion for 60 min. Since somatostatin-like immunoreactivity has been localized to some cells of the thyroid gland being in a parafollicular location, it is suggested that somatostatin may be an intrathyroidal regulator of thyroid activity in man.
研究了生长抑素对人促甲状腺激素（TSH）刺激的甲状腺激素分泌的影响。手术期间向甲状腺动脉注射TSH后，相应甲状腺静脉中的碘甲状腺原氨酸血清浓度升高。当在给予TSH前5分钟经外周静脉推注生长抑素，随后持续输注60分钟时，这种升高显著降低（p<0.02）。由于生长抑素样免疫反应性已定位到甲状腺滤泡旁位置的一些细胞，提示生长抑素可能是人甲状腺内甲状腺活动的调节因子。
