Lalezari P, Nehlsen S L, Sinha S B, Stemerman M B, Veith F J
Immunology. 1974 Sep;27(3):457-62.
Alveolar macrophages of some species have been found to react specifically with several xenogeneic red cells. The reaction, which is detected by spontaneous rosette formation, has two characteristic features. (a) The spontaneous rosettes do not produce, in the absence of exogenous serum proteins, any demonstrable cell-bound immunoglobulins, or divalent ions. These properties distinguish this newly described phenomenon from those known macrophage reactions mediated by cytophilic antibodies or by complement. (b) In contrast to the non-specific reactions of macrophages with inert particles, the reaction described here has distinct specificity and appears to utilize a membrane-associated `receptor'-type mechanism. This receptor is not blocked by anti-globulin but is suppressed by anti-macrophage antibodies. Except for having a wider range of specificity, in some of its characteristics the receptor on macrophages appears to be analogous to the T-cell receptor for xenogeneic red cells. It is suggested that these receptors may play a role in macrophage—T cell co-operation, and in the immune response in general.
已发现某些物种的肺泡巨噬细胞能与几种异种红细胞发生特异性反应。这种反应通过自发形成玫瑰花结来检测，具有两个特征。(a) 在没有外源性血清蛋白或二价离子的情况下，自发形成的玫瑰花结不会产生任何可检测到的细胞结合免疫球蛋白。这些特性将这种新描述的现象与那些已知的由嗜细胞抗体或补体介导的巨噬细胞反应区分开来。(b) 与巨噬细胞与惰性颗粒的非特异性反应不同，这里描述的反应具有明显的特异性，并且似乎利用了一种膜相关的“受体”型机制。这种受体不会被抗球蛋白阻断，但会被抗巨噬细胞抗体抑制。除了具有更广泛的特异性外，巨噬细胞上的这种受体在某些特征上似乎类似于异种红细胞的T细胞受体。有人认为，这些受体可能在巨噬细胞 - T细胞合作以及一般免疫反应中发挥作用。
