Gorczynski R M, Norbury C
Br J Cancer. 1974 Aug;30(2):118-28. doi: 10.1038/bjc.1974.122.
A comparison was made between the cells responsible for demonstrable activity against MSV antigens, using both in vivo and in vitro assays. Similar cells (in terms of size and sensitivity to anti-theta serum) were detected in both assays. However, while lymphoid cells from animals at all stages post-MSV infection were active in protecting irradiated mice from the lethal effect of induction of MSV sarcomata, cells from animals at early stages post-MSV infection (when the tumour was in a progressive phase of growth) were not active in the in vitro assay. By manipulation of the in vivo assay conditions a situation was observed in which cells from "progressor animals" were able to suppress both the in vitro and in vivo activity of regressor lymphoid cells. The potential physiological role of this cell type is disussed.
利用体内和体外试验,对负责对MSV抗原表现出可证实活性的细胞进行了比较。在两种试验中都检测到了相似的细胞(就大小和对抗θ血清的敏感性而言)。然而,虽然MSV感染后各个阶段动物的淋巴细胞在保护受照射小鼠免受MSV肉瘤诱导的致死效应方面具有活性,但MSV感染后早期阶段(肿瘤处于生长进展期)动物的细胞在体外试验中没有活性。通过对体内试验条件的操控,观察到一种情况,即“进展期动物”的细胞能够抑制回归期淋巴细胞的体外和体内活性。讨论了这种细胞类型的潜在生理作用。