对鼠肉瘤病毒诱导肿瘤的免疫。IV. 体外对51Cr标记靶细胞的直接细胞溶解作用以及对调节细胞毒性的阻断因子的分析。
Immunity to murine sarcoma virus induced tumours. IV. Direct cellular cytolysis of 51Cr labelled target cells in vitro and analysis of blocking factors which modulate cytotoxicity.
作者信息
Gorczynski R M, Knight R A
出版信息
Br J Cancer. 1975 Apr;31(4):387-404. doi: 10.1038/bjc.1975.78.
Abstract
The antigen specific cell mediated cytotoxicity of MSV immune spleen lymphocytes to 51Cr labelled murine lymphoma cells was wholly abolished by pretreatment of the spleen cells with anti-theta antibody and complement. Early during the immune response to MSV the cytotoxic acitivity was inhibited by incubation of immune lymphocytes with "late progressor" or "early regressor" serum. Immune lymphocytes at later times were more refractory to such inhibition by serum blocking factors. Although unfractionated cytotoxic lymphocytes, irrespective of the time after MSV infection at which they were tested, were inhibited by soluble tumour associated antigen (TAA), a subpopulation of cytotoxic T cells was identified which was inhibited neither by antigen nor serum.
摘要
用抗θ抗体和补体预处理脾细胞后，MSV免疫脾淋巴细胞对51Cr标记的鼠淋巴瘤细胞的抗原特异性细胞介导的细胞毒性完全消除。在对MSV的免疫反应早期，免疫淋巴细胞与“晚期进展者”或“早期消退者”血清孵育可抑制细胞毒性活性。后期的免疫淋巴细胞对血清阻断因子的这种抑制作用更具抗性。尽管无论在MSV感染后的何时进行测试，未分离的细胞毒性淋巴细胞都受到可溶性肿瘤相关抗原（TAA）的抑制，但已鉴定出一个细胞毒性T细胞亚群，该亚群既不受抗原也不受血清的抑制。
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