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[(3)H]D,L-5-hydroxytryptophan ([(3)H]5HTP) was injected under pressure into cell bodies of identified cholinergic and serotonergic neurones in the central nervous system of the marine mollusc, Aplysia californica.2. Both serotonergic and cholinergic neurones converted [(3)H]5HTP to [(3)H]5-hydroxytryptamine ([(3)H]5HT).3. The fate of [(3)H]5HT in the two types of neurones differed. In serotonergic cells, 5HT was present primarily in particulate form; the transmitter readily moved from cell bodies into nerves by selective transport. In contrast, 5HT remained free in the cytoplasm of the cholinergic neurone, and was not transported from the cell body.4. Treatment of Aplysia with reserpine decreased the proportion of [(3)H]5HT associated with particulate material, and also decreased the amount of [(3)H]5HT recovered.5. Serotonergic neurones possess specific mechanisms for the storage and axonal transport of 5HT which are absent in cholinergic cells.

将[（³H）]D，L - 5 - 羟色氨酸（[（³H）]5HTP）在压力下注射到海洋软体动物加州海兔中枢神经系统中已鉴定的胆碱能和5 - 羟色胺能神经元的细胞体中。
5 - 羟色胺能神经元和胆碱能神经元都将[（³H）]5HTP转化为[（³H）]5 - 羟色胺（[（³H）]5HT）。
[（³H）]5HT在这两种类型神经元中的命运不同。在5 - 羟色胺能细胞中，5HT主要以颗粒形式存在；该递质通过选择性转运容易地从细胞体进入神经。相比之下，5HT在胆碱能神经元的细胞质中保持游离状态，并且不会从细胞体转运出去。
用利血平处理海兔会降低与颗粒物质相关的[（³H）]5HT的比例，并且也会降低回收的[（³H）]5HT的量。
5 - 羟色胺能神经元具有5HT的储存和轴突运输的特定机制，而胆碱能细胞中不存在这些机制。

[(3)H]D,L-5-hydroxytryptophan ([(3)H]5HTP) was injected under pressure into cell bodies of identified cholinergic and serotonergic neurones in the central nervous system of the marine mollusc, Aplysia californica.2. Both serotonergic and cholinergic neurones converted [(3)H]5HTP to [(3)H]5-hydroxytryptamine ([(3)H]5HT).3. The fate of [(3)H]5HT in the two types of neurones differed. In serotonergic cells, 5HT was present primarily in particulate form; the transmitter readily moved from cell bodies into nerves by selective transport. In contrast, 5HT remained free in the cytoplasm of the cholinergic neurone, and was not transported from the cell body.4. Treatment of Aplysia with reserpine decreased the proportion of [(3)H]5HT associated with particulate material, and also decreased the amount of [(3)H]5HT recovered.5. Serotonergic neurones possess specific mechanisms for the storage and axonal transport of 5HT which are absent in cholinergic cells.

将[（³H）]D，L - 5 - 羟色氨酸（[（³H）]5HTP）在压力下注射到海洋软体动物加州海兔中枢神经系统中已鉴定的胆碱能和5 - 羟色胺能神经元的细胞体中。
5 - 羟色胺能神经元和胆碱能神经元都将[（³H）]5HTP转化为[（³H）]5 - 羟色胺（[（³H）]5HT）。
[（³H）]5HT在这两种类型神经元中的命运不同。在5 - 羟色胺能细胞中，5HT主要以颗粒形式存在；该递质通过选择性转运容易地从细胞体进入神经。相比之下，5HT在胆碱能神经元的细胞质中保持游离状态，并且不会从细胞体转运出去。
用利血平处理海兔会降低与颗粒物质相关的[（³H）]5HT的比例，并且也会降低回收的[（³H）]5HT的量。
5 - 羟色胺能神经元具有5HT的储存和轴突运输的特定机制，而胆碱能细胞中不存在这些机制。

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