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[卡介苗接种后机体在给予环磷酰胺及脱敏处理后对肿瘤生长的抵抗力]

[Resistance of BCG-vaccinated body to tumor growth after administration of cyclophosphamide and desensitization].

作者信息

Volegov A I, Trofimchuk S M, Zykov Iu V

出版信息

Biull Eksp Biol Med. 1979 May;87(5):462-5.

PMID:454826
Abstract

It was shown that tumor growth is intensifying as a result of tumor cell implantation not only in early sensitization of BCG-vaccinated organism (see previously published data) but at the later period as well. Cyclophosphan removed this effect whereas desensitization carried out against the background of cyclophosphan action restored it. The data on the relationship between tuberculin allergy and the state of immunological defence reactions of the body suggest the possibility of stimulation of tumor growth as well as of its inhibition.

摘要

结果表明,肿瘤细胞植入不仅在卡介苗接种机体的早期致敏阶段(见先前发表的数据)会导致肿瘤生长加剧,在后期也会如此。环磷酰胺可消除这种效应,而在环磷酰胺作用背景下进行的脱敏则会恢复这种效应。关于结核菌素过敏与机体免疫防御反应状态之间关系的数据表明,存在刺激肿瘤生长以及抑制肿瘤生长的可能性。

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