5-羟色氨酸的降血糖作用。
The hypoglycaemic effect of 5-hydroxytryptophan.
作者信息
Furman B L
出版信息
Br J Pharmacol. 1974 Apr;50(4):575-80. doi: 10.1111/j.1476-5381.1974.tb08591.x.
Abstract
1 In nialamide-treated mice, L-5-hydroxytryptophan produced a dose-dependent hypoglycaemic response which was independent of whether the animals had been fed or fasted.2 This response was accompanied by a head-twitching response which was also dose-dependent.3 The hypoglycaemic response was not accompanied by an elevation in plasma immunoreactive insulin levels and was fully manifest in alloxan diabetic animals.4 5-Hydroxytryptophan did not increase the in vitro glucose uptake of adipose tissue or skeletal muscle, either on incubation of the tissues in contact with the drug or on incubation of tissues removed from mice injected with the drug.5 Both the hypoglycaemic and head-twitching responses were prevented by pretreatment with methysergide or cyproheptadine and augmented by mepyramine treatment.
摘要
在接受尼亚酰胺治疗的小鼠中，L - 5 - 羟色氨酸产生了剂量依赖性的低血糖反应，该反应与动物是否进食或禁食无关。
这种反应伴有头部抽搐反应，该反应也是剂量依赖性的。
低血糖反应并未伴随血浆免疫反应性胰岛素水平的升高，并且在四氧嘧啶糖尿病动物中完全显现。
无论是将组织与药物接触孵育，还是将从注射该药物的小鼠身上取出的组织孵育，5 - 羟色氨酸均未增加脂肪组织或骨骼肌的体外葡萄糖摄取。
低血糖和头部抽搐反应均通过麦角新碱或赛庚啶预处理得以预防，并通过美吡拉敏治疗而增强。
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本文引用的文献
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