苯并三嗪碘化物和奎尼丁对豚鼠心脏作用的比较。
Comparison of the effects of a benzotriazinium iodide and quinidine on guinea-pig heart.
作者信息
French A M, Scott N C
出版信息
Br J Pharmacol. 1979 May;66(1):19-24. doi: 10.1111/j.1476-5381.1979.tb16092.x.
Abstract
1 The actions of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI) and quinidine were compared on guinea-pig heart preparations. 2 Quinidine had negative inotropic and chronotropic effects on guinea-pig isolated atria and on Langendorff hearts: TnPBI had negative inotropic and chronotropic effects on Langendorff hearts, but showed a positive inotropic effect on isolated atria at low dose levels. 3 Both quinidine and TnPBI increased the effective refractory period of guinea-pig atrial preparations. 4 The effects of TnPBI on transmembrane action potentials indicated a mixed class I and class III action according to the classification of Vaughan Williams (1970). 5 These effects are discussed in relation to the antiarrhythmic actions of TnPBI.
摘要
- 比较了2-正丙基-4-对甲苯氨基-1,2,3-苯并三嗪碘化物（TnPBI）和奎尼丁对豚鼠心脏制剂的作用。2. 奎尼丁对豚鼠离体心房和Langendorff心脏有负性肌力和负性变时作用：TnPBI对Langendorff心脏有负性肌力和负性变时作用，但在低剂量水平对离体心房表现出正性肌力作用。3. 奎尼丁和TnPBI均延长了豚鼠心房制剂的有效不应期。4. 根据Vaughan Williams（1970年）的分类，TnPBI对跨膜动作电位的作用表明其具有I类和III类混合作用。5. 结合TnPBI的抗心律失常作用对这些作用进行了讨论。
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