咖啡因与一种2-烷基-1,2,3-苯并三嗪碘化物对青蛙腹直肌作用的比较。
Comparison of the effects of caffeine and a 2-alkyl-1,2,3-benzotriazinium iodide on frog rectus abdominis.
作者信息
Muir C K, Scott N C
出版信息
Br J Pharmacol. 1977 Jul;60(3):375-8. doi: 10.1111/j.1476-5381.1977.tb07511.x.
Abstract
1 The mode of action of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI), which induced contractures of frog rectus abdominis muscle, was investigated. 2 TnPBI caused contractures of frog rectus abdominis when the muscle had been depolarized with potassium chloride. 3 Experiments with TnPBI and caffeine in calcium-free Ringer suggested that both compounds produce contractures by releasing intracellular bound calcium. 4 It is suggested that at least two calcium stores are involved, one of which is sensitive to caffeine while both are sensitive to TnPBI.
摘要
- 研究了2-正丙基-4-对甲苯氨基-1,2,3-苯并三嗪碘化物（TnPBI）诱导青蛙腹直肌挛缩的作用方式。2. 当用氯化钾使青蛙腹直肌去极化时，TnPBI会引起其挛缩。3. 在无钙林格液中用TnPBI和咖啡因进行的实验表明，这两种化合物都是通过释放细胞内结合钙来产生挛缩的。4. 提示至少涉及两个钙储存库，其中一个对咖啡因敏感，而两个都对TnPBI敏感。
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