短小棒状杆菌处理的小鼠的肿瘤生长、吞噬活性及抗体反应
Tumour growth, phagocytic activity and antibody response in Corynebacterium parvum-treated mice.
作者信息
Woodruff M F, McBride W H, Dunbar N
出版信息
Clin Exp Immunol. 1974 Jul;17(3):509-18.
Abstract
Serum from both normal and T cell-deprived female adult CBA mice shows a background titre of antibody to of about 2–4 log units by a latex agglutination test. Intraperitoneal injection of causes a marked rise in titre which reaches its peak after about a month, and a second injection at that time evokes a further response. Treatment with mercaptoethanol reduces the background titre, and also the titre 1–3 weeks after immunization by 1–2 log units. Subcutaneous injection of on the other hand evokes little or no antibody response. Both the antitumour effect of , and its effect on clearance of colloidal carbon from the blood stream, can occur in the presence of high levels of antibody directed against the organism. Theoretical and possible therapeutic implications of these findings are discussed.
摘要
通过乳胶凝集试验，正常和T细胞缺失的成年雌性CBA小鼠的血清显示出针对……的抗体背景滴度约为2 - 4个对数单位。腹腔注射……会导致滴度显著升高，约一个月后达到峰值，此时再次注射会引发进一步反应。用巯基乙醇处理可降低背景滴度，以及免疫后1 - 3周的滴度，降低1 - 2个对数单位。另一方面，皮下注射……几乎不引发或不引发抗体反应。在存在高水平针对该生物体的抗体的情况下，……的抗肿瘤作用及其对胶体碳从血流中清除的作用都可能发生。讨论了这些发现的理论和可能的治疗意义。
相似文献
1
Tumour growth, phagocytic activity and antibody response in Corynebacterium parvum-treated mice.短小棒状杆菌处理的小鼠的肿瘤生长、吞噬活性及抗体反应
Clin Exp Immunol. 1974 Jul;17(3):509-18.
2
Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.局部注射短小棒状杆菌对小鼠纤维肉瘤生长的影响。
Br J Cancer. 1975 Jul;32(1):34-41. doi: 10.1038/bjc.1975.131.
3
Antitumor antibodies and immunoglobulin class and subclass levels in Corynebacterium parvum-treated mice.短小棒状杆菌处理的小鼠体内的抗肿瘤抗体及免疫球蛋白类别和亚类水平
J Natl Cancer Inst. 1976 May;56(5):1035-40. doi: 10.1093/jnci/56.5.1035.
4
The effect of Corynebacterium parvum on T cell dependent tumor regression.短小棒状杆菌对T细胞依赖性肿瘤消退的作用。
J Reticuloendothel Soc. 1980 Feb;27(2):151-8.
5
6
In vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with Corynebacterium parvum: reduced effect in irradiated recipients.用短小棒状杆菌处理的小鼠腹腔渗出细胞在体内抗肿瘤活性的转移：在受辐照受体中作用减弱。
J Natl Cancer Inst. 1977 Sep;59(3):881-7. doi: 10.1093/jnci/59.3.881.
7
The mechanism of inhibition by Corynebacterium parvum of the growth of lung nodules from intravenously injected tumour cells.微小棒状杆菌对静脉注射肿瘤细胞所致肺结节生长的抑制机制。
Int J Cancer. 1974 Aug 15;14(2):226-35. doi: 10.1002/ijc.2910140211.
8
[Effect of silica on the anti-tumour activity of "Corynebacterium parvum" (author's transl)].二氧化硅对“短小棒状杆菌”抗肿瘤活性的影响（作者译）
Ann Immunol (Paris). 1979 Nov-Dec;130(6):815-26.
9
Enhancement and depression of the antibody response in mice caused by Corynebacterium parvum.微小棒状杆菌引起的小鼠抗体反应的增强与抑制
Clin Exp Immunol. 1974 Jul;17(3):519-32.
10
Possible mechanisms in the anti-tumour activity of C. parvum.微小隐孢子虫抗肿瘤活性的可能机制。
Dev Biol Stand. 1977;38:265-71.
引用本文的文献
1
Therapeutic Effects of and Lipopolysaccharide from in Cats with Feline Panleukopenia.来自[具体来源不明]的[物质不明]和脂多糖对猫泛白细胞减少症的治疗作用。
Vet Sci. 2024 Jun 4;11(6):253. doi: 10.3390/vetsci11060253.
2
The long-standing history of Corynebacterium parvum, immunity, and viruses.短小棒状杆菌的悠久历史、免疫与病毒。
J Med Virol. 2020 Nov;92(11):2429-2439. doi: 10.1002/jmv.26100. Epub 2020 Jun 29.
3
Killed Propionibacterium acnes enhances immunogenicity and tumor growth control of a dendritic-tumor cell hybrid vaccine in a murine melanoma model.杀痤疮丙酸杆菌增强树突状细胞瘤融合疫苗在小鼠黑色素瘤模型中的免疫原性和肿瘤生长抑制作用。
PLoS One. 2018 Oct 9;13(10):e0205148. doi: 10.1371/journal.pone.0205148. eCollection 2018.
4
Enhances the Immunogenicity of HIVBr18 Human Immunodeficiency Virus-1 Vaccine.增强 HIVBr18 型人类免疫缺陷病毒 1 型疫苗的免疫原性。
Front Immunol. 2018 Feb 7;9:177. doi: 10.3389/fimmu.2018.00177. eCollection 2018.
5
Specific humoral immune response induced by propionibacterium acnes can prevent Actinobacillus pleuropneumoniae infection in mice.痤疮丙酸杆菌诱导的特异性体液免疫反应可预防小鼠胸膜肺炎放线杆菌感染。
Clin Vaccine Immunol. 2014 Mar;21(3):407-16. doi: 10.1128/CVI.00667-13. Epub 2014 Jan 15.
6
Adjuvant effect of killed Propionibacterium acnes on mouse peritoneal B-1 lymphocytes and their early phagocyte differentiation.痤疮丙酸杆菌死菌对小鼠腹腔 B-1 淋巴细胞及其早期吞噬细胞分化的辅助作用。
PLoS One. 2012;7(3):e33955. doi: 10.1371/journal.pone.0033955. Epub 2012 Mar 20.
7
Salmonella-allies in the fight against cancer.沙门氏菌盟友助力抗击癌症。
J Mol Med (Berl). 2010 Aug;88(8):763-73. doi: 10.1007/s00109-010-0636-z. Epub 2010 Jun 5.
8
Biphasic protection against bacterial infection in mice induced by vaccination of Propionibacterium acnes.痤疮丙酸杆菌疫苗接种诱导的小鼠对细菌感染的双相保护作用。
Infect Immun. 1980 Feb;27(2):391-6. doi: 10.1128/iai.27.2.391-396.1980.
9
Immune reaction of tumor-bearing mice to Propionibacterium acnes and the antitumor effect of the bacteria.荷瘤小鼠对痤疮丙酸杆菌的免疫反应及该细菌的抗肿瘤作用。
Cancer Immunol Immunother. 1982;14(1):10-2. doi: 10.1007/BF00199425.
10
Effect of Corynebacterium granulosum immunopotentiation on the pathogenesis of herpes simplex virus type 2 in BALB/c mice.颗粒棒状杆菌免疫增强对BALB/c小鼠2型单纯疱疹病毒发病机制的影响。
Infect Immun. 1980 Dec;30(3):791-6. doi: 10.1128/iai.30.3.791-796.1980.
本文引用的文献
1
[STIMULATION OF THE PHAGOCYTIC ACTIVITY OF THE RETICULOENDOTHELIAL SYSTEM BY CORYNEBACTERIUM PARVUM].[短小棒状杆菌对网状内皮系统吞噬活性的刺激作用]
J Reticuloendothel Soc. 1964 Jan;1:77-96.
2
A latex agglutination test for anaerobic diphtheroids.
Proc Soc Exp Biol Med. 1960 Aug-Sep;104:683-5. doi: 10.3181/00379727-104-25951.
3
[Quantitative study of the granulopectic activity of the reticuloendothelial system of mice].[小鼠网状内皮系统粒细胞吞噬活性的定量研究]
C R Seances Soc Biol Fil. 1954 Mar;148(5-6):431-5.
4
Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts.短小棒状杆菌注射液对同基因宿主肿瘤移植生长的抑制作用。
Br J Cancer. 1966 Jun;20(2):345-55. doi: 10.1038/bjc.1966.42.
5
Cell wall composition and deoxyribonucleic acid similarities among the anaerobic coryneforms, classical propionibacteria, and strains of Arachnia propionica.厌氧棒状杆菌、经典丙酸杆菌和丙酸蛛网菌菌株之间的细胞壁组成及脱氧核糖核酸相似性
J Bacteriol. 1972 Mar;109(3):1047-66. doi: 10.1128/jb.109.3.1047-1066.1972.
6
Further observations on the effect of C. parvum and anti-tumour globulin on syngeneically transplanted mouse tumours.微小隐孢子虫和抗肿瘤球蛋白对同基因移植小鼠肿瘤影响的进一步观察
Br J Cancer. 1972 Apr;26(2):67-76. doi: 10.1038/bjc.1972.11.
7
The growth of tumours in T-cell deprived mice and their response to treatment with Corynebacterium parvum.T细胞缺失小鼠体内肿瘤的生长及其对微小棒状杆菌治疗的反应。
Proc R Soc Lond B Biol Sci. 1973 Aug 31;184(1074):97-102. doi: 10.1098/rspb.1973.0034.
8
Active immunotherapy for cancer.
Lancet. 1973 Sep 29;2(7831):737-8. doi: 10.1016/s0140-6736(73)92571-3.
9
Synergistic inhibition of mammary carcinoma transplants in A-strain mice by antitumour globulin and C. parvum.抗肿瘤球蛋白和微小隐孢子虫对A系小鼠乳腺癌移植瘤的协同抑制作用
Br J Cancer. 1971 Sep;25(3):584-93. doi: 10.1038/bjc.1971.74.
Zotero 插件