Guicheney P, Zorn J R, Rey E, Sureau C, Olive G
Eur J Obstet Gynecol Reprod Biol. 1978 Apr;8(2):89-94. doi: 10.1016/0028-2243(78)90133-8.
Hypoxanthine levels were determined in both venous and arterial cord blood of 42 neonates. Two methods were compared, a PO2 electrode determination and an HPLC (high-pressure liquid chromatography) method. A good correlation was found between the two methods. However, the HPLC method was more sensitive, more reproducible and easier to perform. Hypoxanthine levels in the umbilical artery were found to be higher than in the vein. A significant negative correlation between pH and hypoxanthine level was established. The studies showed that plasma hypoxanthine levels by themselves did not provide an absolute diagnosis of intrauterine hypoxia.
对42例新生儿的静脉血和动脉血中的次黄嘌呤水平进行了测定。比较了两种方法，一种是用PO2电极测定法，另一种是高效液相色谱（HPLC）法。发现这两种方法之间有良好的相关性。然而，HPLC法更灵敏、更具可重复性且操作更简便。发现脐动脉中的次黄嘌呤水平高于静脉中的水平。建立了pH值与次黄嘌呤水平之间显著的负相关关系。研究表明，血浆次黄嘌呤水平本身并不能提供宫内缺氧的绝对诊断依据。
