西咪替丁对大鼠实验性慢性胃溃疡的作用。
Effect of cimetidine on chronic gastric ulcers produced experimentally in rats.
作者信息
MacPherson B R, Kilam S K
出版信息
Can J Surg. 1979 Jul;22(4):385-7.
PMID:455171
Abstract
The authors have studied the effects of cimetidine on the healing of chronic gastric ulcers induced in rats. Gastric ulcers were produced by topical application of 60% acetic acid to the serosal surface of the lesser curvature of the stomach. Oral administration of cimetidine, 150 mg/kg daily, in two divided doses for a maximum of 14 days failed to produce any significant acceleration of healing.
摘要
作者研究了西咪替丁对大鼠慢性胃溃疡愈合的影响。通过将60%的醋酸局部涂抹于胃小弯的浆膜表面来制造胃溃疡。每天口服西咪替丁150毫克/千克，分两次给药，最长给药14天，未能显著加速溃疡愈合。
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