西咪替丁对应激性溃疡的作用。
The effect of cimetidine on stress ulcers.
作者信息
Sufian S, Sugimachi K, Leahy J A, Matsumoto T
出版信息
Int Surg. 1978 Mar;63(3):143-6.
We used 135 male Wistar rats. Stress ulcers were formed with standard methods of restraints and cold. The severity of the ulcer was graded from 0--3 and determined for each group. Ulcers occurred in the glandular portion of the stomach. Pre- and post-treatment with cimetidine was compared with controls and pre-treatment with saline or antacid. Cimetidine was significantly more effective in preventing stress-induced ulcers in rats when instilled in the stomach before the stress than either antacid or saline.
我们使用了135只雄性Wistar大鼠。采用标准的束缚和寒冷方法形成应激性溃疡。对溃疡的严重程度按照0至3级进行分级，并针对每组进行测定。溃疡发生在胃的腺体部分。将西咪替丁治疗前后的情况与对照组以及用生理盐水或抗酸剂预处理的情况进行比较。当在应激前将西咪替丁注入胃内时，其在预防大鼠应激性溃疡方面比抗酸剂或生理盐水显著更有效。
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