甲基黄嘌呤诱导的增强：在培养中发育的骨骼肌中观察到的一种传播波现象。

Coleman A W, Coleman J R, Griffin J D, Weltman J K, Chapman K M

Proc Natl Acad Sci U S A. 1972 Mar;69(3):613-6. doi: 10.1073/pnas.69.3.613.

Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin; the effect on escalation is not. Escalation is prevented by removal of external Ca(++) or by the addition of tetracaine.

相对低浓度的甲基黄嘌呤会增加培养的肌纤维中的自发抽搐；它们还会引发第二种活动，即增强，这是可见波的起始和持续传播。对抽搐的影响可通过去极化浓度的K(+)或河豚毒素消除；对增强的影响则不然。去除细胞外Ca(++)或添加丁卡因可防止增强。