髓母细胞瘤放疗后发生的甲状腺肿瘤：两例报告。
Thyroid neoplasia following irradiation for medulloblastoma: report of two cases.
作者信息
Roggli V L, Estrada R, Fechner R E
出版信息
Cancer. 1979 Jun;43(6):2232-8. doi: 10.1002/1097-0142(197906)43:6<2232::aid-cncr2820430612>3.0.co;2-u.
Thyroid neoplasms occurred in two patients 14 and 18 years after treatment with radiation for medulloblastoma. One patient has a papillary cancer and the other patient had multiple adenomas and a Hurthle cell adenoma. In addition, the latter case had foci of hyperplasia plus a microfollicular transformation, which has not been described in association with prior thyroid irradiation. The radiation doses delivered to the thyroid through posterior cervical spinal ports (2000--3000 roentgens) fall within the upper range of radiation dosage associated with induction of neoplastic changes within the thyroid.
甲状腺肿瘤发生在两名因髓母细胞瘤接受放射治疗后14年和18年的患者身上。一名患者患有乳头状癌，另一名患者有多个腺瘤和一个许特莱细胞腺瘤。此外，后一例患者还有增生灶以及微滤泡化生，此前甲状腺放疗相关情况中尚未描述过这种情况。通过后颈部脊髓野给予甲状腺的辐射剂量（2000 - 3000伦琴）处于与甲状腺内肿瘤性改变诱导相关的辐射剂量上限范围内。
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