Roudebush C P, Asteris G T, DeGroot L J
Arch Intern Med. 1978 Nov;138(11):1631-4.
The clinical courses of 91 patients with radiation-associated thyroid cancer were compared with courses in a control population. Radiation-associated carcinoma appears to be a disease of younger persons, and 90% of the tumors are papillary. No anaplastic or medullary tumors were observed. Ninety percent of the tumors were larger than those found in an autopsy series that surveyed for "biologically benign" thyroid tumors. There was a higher incidence of multicentric disease, locally invasive disease, and distant metastases in the population that had had x-ray exposure. Although the population with x-ray exposure had had more aggressive treatment, more recurrences were present in patients who had had radiation therapy. The death rate was similar in both groups. Parathyroid adenoma occurred more frequently in the population that had radiation exposure than in controls and appears to be a radiation-associated illness.
对91例放射性相关甲状腺癌患者的临床病程与对照人群的病程进行了比较。放射性相关癌似乎是一种发生于较年轻人群的疾病，90%的肿瘤为乳头状癌。未观察到间变性或髓样肿瘤。90%的肿瘤比在一项针对“生物学良性”甲状腺肿瘤的尸检系列中发现的肿瘤更大。接受过X线照射的人群中多中心疾病、局部侵袭性疾病和远处转移的发生率更高。尽管接受过X线照射的人群接受了更积极的治疗，但接受放射治疗的患者中复发情况更多。两组的死亡率相似。甲状旁腺腺瘤在接受放射照射的人群中比在对照组中更频繁出现，似乎是一种与放射相关的疾病。
