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Uric acid metabolism in dalmatians and other dogs. Role of the liver.

作者信息

Kuster G, Shorter R G, Dawson B, Hallenbeck G A

出版信息

Arch Intern Med. 1972 Mar;129(3):492-6.

PMID:4552898
Abstract
摘要

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Uric acid metabolism in dalmatians and other dogs. Role of the liver.
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Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog.SLC2A9基因的突变会导致犬类出现高尿酸尿症和高尿酸血症。
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Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA03.通过杂交回交进行的连锁分析将大麦町犬高尿酸尿症定位到犬染色体03（CFA03）。
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Normal urate transport into erythrocytes in familial renal hypouricemia and in the Dalmatian dog.家族性肾性低尿酸血症和达尔马提亚犬中尿酸向红细胞的正常转运。
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