• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

大麦町犬肝脏中尿酸摄取缺陷。

Defect of uric acid uptake in Dalmatian dog liver.

作者信息

Giesecke D, Tiemeyer W

出版信息

Experientia. 1984 Dec 15;40(12):1415-6. doi: 10.1007/BF01951919.

DOI:10.1007/BF01951919
PMID:6510499
Abstract

The uptake rate of uric acid into liver slices of the Dalmatian dog was found to be significantly lower compared with that in the beagle. Since there was no difference in the hepatic uricase activity between the two breeds, the abnormality of uric acid metabolism in the Dalmatian dog is considered to result from a defective hepatic transport system for uric acid.

摘要

研究发现,与比格犬相比,大麦町犬肝脏切片对尿酸的摄取率显著降低。由于两个品种的肝脏尿酸酶活性没有差异,因此认为大麦町犬尿酸代谢异常是由肝脏尿酸转运系统缺陷所致。

相似文献

1
Defect of uric acid uptake in Dalmatian dog liver.大麦町犬肝脏中尿酸摄取缺陷。
Experientia. 1984 Dec 15;40(12):1415-6. doi: 10.1007/BF01951919.
2
Low uricase activity in the Dalmatian dog simulated in mongrels given oxonic acid.
Am J Physiol. 1971 Apr;220(4):973-9. doi: 10.1152/ajplegacy.1971.220.4.973.
3
[Why Dalmatians excrete uric acid. Causes and consequences of a classical metabolic disorder].[为什么大麦町犬会排泄尿酸。一种典型代谢紊乱的原因及后果]
Tierarztl Prax. 1985;13(3):331-41.
4
Uric acid uptake in erythrocytes of beagle and dalmatian dogs.
Comp Biochem Physiol A Comp Physiol. 1986;85(3):417-21. doi: 10.1016/0300-9629(86)90423-8.
5
The Dalmatian defect: a hepatic endocrinopathy of urate transport.大麦町犬缺陷:一种尿酸转运的肝脏内分泌病。
Arthritis Rheum. 2005 Aug;52(8):2257-62. doi: 10.1002/art.21241.
6
Exclusion of urate oxidase as a candidate gene for hyperuricosuria in the Dalmatian dog using an interbreed backcross.利用品种间回交法排除尿酸氧化酶作为大麦町犬高尿酸尿症候选基因的可能性。
J Hered. 2005;96(7):750-4. doi: 10.1093/jhered/esi078. Epub 2005 Jun 15.
7
The fate of administered purines in the Dalmatian coach hound.
J Comp Pathol. 1986 May;96(3):267-76. doi: 10.1016/0021-9975(86)90046-0.
8
Enzymatic degradation of uric acid by uricase-loaded human erythrocytes.尿酸酶负载的人红细胞对尿酸的酶促降解作用。
J Clin Invest. 1975 Sep;56(3):595-602. doi: 10.1172/JCI108129.
9
Normal urate transport into erythrocytes in familial renal hypouricemia and in the Dalmatian dog.家族性肾性低尿酸血症和达尔马提亚犬中尿酸向红细胞的正常转运。
Can Med Assoc J. 1983 Mar 1;128(5):545-9.
10
Net urate reabsorption in the Dalmatian coach hound with a note on automated measurement of urate in species with low plasma urate.
Can J Physiol Pharmacol. 1982 Dec;60(12):1499-504. doi: 10.1139/y82-221.

引用本文的文献

1
Stones in cats and dogs: What can be learnt from them?猫和狗身上的结石:我们能从中学到什么?
Arab J Urol. 2012 Sep;10(3):230-9. doi: 10.1016/j.aju.2012.06.006. Epub 2012 Aug 15.
2
Primary portal vein hypoplasia and SLC2A9 mutation associated with urate urolithiasis in a Spanish water dog.西班牙水犬原发性门静脉发育不全和SLC2A9突变与尿酸盐尿石症相关
Can Vet J. 2015 Nov;56(11):1153-7.
3
Ultrasound-guided percutaneous antegrade pyelography with computed tomography for the diagnosis of spontaneous partial ureteral rupture in a dog.

本文引用的文献

1
Observations concerning the causes of the excess excretion of uric acid in the Dalmatian dog.关于达尔马提亚狗尿酸排泄过多原因的观察
J Biol Chem. 1948 Sep;175(2):727-35.
2
Extracellular space estimation in rat kidney slices using C saccharides and phlorizin.使用C糖类和根皮苷对大鼠肾切片进行细胞外空间估计。
Am J Physiol. 1962 Apr;202:800-4. doi: 10.1152/ajplegacy.1962.202.4.800.
3
URIC ACID TRANSPORT SYSTEM: APPARENT ABSENCE IN ERYTHROCYTES OF THE DALMATIAN COACH HOUND.
Science. 1964 Aug 21;145(3634):826-7. doi: 10.1126/science.145.3634.826.
超声引导下经皮顺行肾盂造影联合计算机断层扫描诊断犬自发性部分输尿管破裂
Can Vet J. 2012 Nov;53(11):1187-90.
4
Feline urate urolithiasis: a retrospective study of 159 cases.猫尿酸盐尿石症:159例回顾性研究
J Feline Med Surg. 2011 Oct;13(10):725-32. doi: 10.1016/j.jfms.2011.07.001. Epub 2011 Aug 12.
5
Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers.斗牛犬和黑俄罗斯梗犬高尿酸尿症尿液检测的验证及假定基因突变的特征分析。
Am J Vet Res. 2010 Aug;71(8):909-14. doi: 10.2460/ajvr.71.8.909.
6
Epidemiological association between uric acid concentration in plasma, lipoprotein(a), and the traditional lipid profile.血浆尿酸浓度、脂蛋白(a)与传统血脂谱的流行病学关联。
Clin Cardiol. 2010 Feb;33(2):E76-80. doi: 10.1002/clc.20511.
7
Changing paradigms in diagnosis of inherited defects associated with urolithiasis.与尿石症相关的遗传性缺陷诊断中的范式转变
Vet Clin North Am Small Anim Pract. 2009 Jan;39(1):111-25. doi: 10.1016/j.cvsm.2008.09.006.
8
Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog.SLC2A9基因的突变会导致犬类出现高尿酸尿症和高尿酸血症。
PLoS Genet. 2008 Nov;4(11):e1000246. doi: 10.1371/journal.pgen.1000246. Epub 2008 Nov 7.
9
Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA03.通过杂交回交进行的连锁分析将大麦町犬高尿酸尿症定位到犬染色体03(CFA03)。
Mamm Genome. 2006 Apr;17(4):340-5. doi: 10.1007/s00335-005-0137-5. Epub 2006 Apr 4.
10
[Effects of purine-rich nutrition on the renal and extrarenal excretion of purine catabolites in Dalmatian dogs].
Z Ernahrungswiss. 1990 Sep;29(3):208-18. doi: 10.1007/BF02021560.
4
Tubular secretion of urate in the dog.狗体内尿酸盐的肾小管分泌
Am J Physiol. 1960 Dec;199:1199-204. doi: 10.1152/ajplegacy.1960.199.6.1199.
5
Availability and metabolism of purines of single-cell proteins in monogastric animals.单胃动物中单细胞蛋白嘌呤的可利用性与代谢
Proc Nutr Soc. 1982 Sep;41(3):319-27. doi: 10.1079/pns19820047.
6
Purine availability and metabolism in dogs fed single-cell protein or RNA.
J Nutr. 1982 Oct;112(10):1822-6. doi: 10.1093/jn/112.10.1822.
7
Bidirectional urate transport limited to the proximal tubule in dogs.双向尿酸盐转运仅限于犬的近端小管。
Am J Physiol. 1968 Aug;215(2):411-22. doi: 10.1152/ajplegacy.1968.215.2.411.
8
Renal excretion of uric acid in the dog.狗体内尿酸的肾脏排泄。
Am J Physiol. 1968 Aug;215(2):404-10. doi: 10.1152/ajplegacy.1968.215.2.404.
9
Low uricase activity in the Dalmatian dog simulated in mongrels given oxonic acid.
Am J Physiol. 1971 Apr;220(4):973-9. doi: 10.1152/ajplegacy.1971.220.4.973.
10
Uric acid metabolism in dalmatians and other dogs. Role of the liver.
Arch Intern Med. 1972 Mar;129(3):492-6.