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1
Comparison of the substrate specificities of the -lactamases from Klebsiella aerogenes 1082E and Enterobacter cloacae P99.产气克雷伯菌1082E和阴沟肠杆菌P99的β-内酰胺酶底物特异性比较。
Appl Microbiol. 1972 Apr;23(4):765-9. doi: 10.1128/am.23.4.765-769.1972.
2
Relation of beta-lactamase activity and cellular location to resistance of Enterobacter to penicillins and cephalosporins.β-内酰胺酶活性及细胞定位与肠杆菌对青霉素和头孢菌素耐药性的关系。
Antimicrob Agents Chemother. 1972 Feb;1(2):107-11. doi: 10.1128/AAC.1.2.107.
3
Interaction between carbenicillin and beta-lactamases from Gram-negative bacteria.羧苄青霉素与革兰氏阴性菌β-内酰胺酶之间的相互作用。
J Gen Microbiol. 1971 Nov;68(3):263-72. doi: 10.1099/00221287-68-3-263.
4
Some relationships between R-factor and chromosomal -lactamase in Gram-negative bacteria.革兰氏阴性菌中R因子与染色体β-内酰胺酶之间的一些关系。
Biochem J. 1971 Jul;123(4):507-12. doi: 10.1042/bj1230507.
5
Characterization of the chromosomally mediated penicillinase in Klebsiella pneumoniae.肺炎克雷伯菌中染色体介导的青霉素酶的特性分析。
Jpn J Microbiol. 1972 May;16(3):169-76. doi: 10.1111/j.1348-0421.1972.tb00645.x.
6
Inhibition of Aerobacter cephalosporin beta-lactamase by penicillins.青霉素对产气杆菌头孢菌素β-内酰胺酶的抑制作用。
J Bacteriol. 1969 May;98(2):394-7. doi: 10.1128/jb.98.2.394-397.1969.
7
Lytic activity of a new cephalosporin, cefuroxime, against gram-negative bacteria.新型头孢菌素头孢呋辛对革兰氏阴性菌的溶菌活性。
Chemotherapy. 1978;24(6):354-9. doi: 10.1159/000237807.
8
Resistance of penicillins and cephalosporins to beta-lactamases from Gram-negative bacilli: some correlations with antibacterial activity.青霉素和头孢菌素对革兰氏阴性杆菌β-内酰胺酶的耐药性：与抗菌活性的一些相关性。
Ann N Y Acad Sci. 1967 Sep 27;145(2):237-47. doi: 10.1111/j.1749-6632.1967.tb50222.x.
9
Hydrolysis of cephalosporins by beta-lactamases from gram-negative bacteria.革兰氏阴性菌的β-内酰胺酶对头孢菌素的水解作用。
Nature. 1967 Jun 24;214(5095):1333-4. doi: 10.1038/2141333a0.
10
Comparison of assay techniques for beta-lactamase activity.β-内酰胺酶活性检测技术的比较
Anal Biochem. 1973 Jul;54(1):9-16. doi: 10.1016/0003-2697(73)90241-8.

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1
Genome sequence-based identification of strains and description of sp. nov.基于基因组序列的 菌株鉴定和 种的描述。
Microbiol Spectr. 2024 Jan 11;12(1):e0315023. doi: 10.1128/spectrum.03150-23. Epub 2023 Dec 15.
2
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.NXL104 对 TEM-1 和 P99 的抑制作用及其机制研究。NXL104 是一种新型非β-内酰胺类β-内酰胺酶抑制剂。
Antimicrob Agents Chemother. 2010 Dec;54(12):5132-8. doi: 10.1128/AAC.00568-10. Epub 2010 Oct 4.
3
Effect of chelating agents on the susceptibility of some strains of gram-negative bacteria to some antibacterial agents.螯合剂对某些革兰氏阴性菌菌株对某些抗菌剂敏感性的影响。
Antimicrob Agents Chemother. 1974 Aug;6(2):200-6. doi: 10.1128/AAC.6.2.200.
4
The extended-spectrum K1 beta-lactamase from Klebsiella oxytoca SC 10,436 is a member of the bla(OXY-2) family of chromosomal Klebsiella enzymes.来自产酸克雷伯菌SC 10436的超广谱K1β-内酰胺酶是染色体克雷伯菌酶bla(OXY-2)家族的成员。
Antimicrob Agents Chemother. 2002 Jun;46(6):2056-7. doi: 10.1128/AAC.46.6.2056-2057.2002.
5
A functional classification scheme for beta-lactamases and its correlation with molecular structure.β-内酰胺酶的功能分类方案及其与分子结构的相关性。
Antimicrob Agents Chemother. 1995 Jun;39(6):1211-33. doi: 10.1128/AAC.39.6.1211.
6
Principal beta-lactamases responsible for resistance to beta-lactam antibiotics in urinary tract infections.导致尿路感染对β-内酰胺类抗生素耐药的主要β-内酰胺酶。
Antimicrob Agents Chemother. 1980 Jun;17(6):929-36. doi: 10.1128/AAC.17.6.929.
7
Rapid, inexpensive method for specific detection of microbial beta-lactamases by detection of fluorescent end products.通过检测荧光终产物特异性检测微生物β-内酰胺酶的快速、廉价方法。
J Clin Microbiol. 1984 Jun;19(6):818-25. doi: 10.1128/jcm.19.6.818-825.1984.
8
Chromosomal beta-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins.阴沟肠杆菌的染色体β-内酰胺酶是导致对第三代头孢菌素耐药的原因。
Antimicrob Agents Chemother. 1983 Jun;23(6):918-25. doi: 10.1128/AAC.23.6.918.
9
Purification of beta-lactamases by affinity chromatography on phenylboronic acid-agarose.通过苯基硼酸 - 琼脂糖亲和层析法纯化β - 内酰胺酶。
Biochem J. 1984 Jul 15;221(2):505-12. doi: 10.1042/bj2210505.
10
Molecular hybridization versus isoelectric focusing to determine TEM-type beta-lactamases in gram-negative bacteria.采用分子杂交法与等电聚焦法检测革兰氏阴性菌中的TEM型β-内酰胺酶
Antimicrob Agents Chemother. 1987 Feb;31(2):300-5. doi: 10.1128/AAC.31.2.300.

本文引用的文献

1
Differences between pencillinases from gram-positive and gram-negative bacteria.革兰氏阳性菌和革兰氏阴性菌青霉素酶之间的差异。
Nature. 1963 Mar 9;197:976-8. doi: 10.1038/197976a0.
2
Observations on the nature, distribution, and significance of cephalosporinase.关于头孢菌素酶的性质、分布及意义的观察
Lancet. 1963 Jun 29;1(7296):1399-401. doi: 10.1016/s0140-6736(63)92051-8.
3
Iodometric assay of penicillinase.青霉素酶的碘量法测定
Nature. 1954 Nov 27;174(4439):1012-3. doi: 10.1038/1741012a0.
4
Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae.肠杆菌科中由传染性R因子控制的青霉素酶合成
Nature. 1965 Oct 16;208(5007):239-41. doi: 10.1038/208239a0.
5
Drug resistance of enteric bacteria. XIV. Comparison of beta-lactamases in gram-negative rod bacteria resistant to alpha-aminobenzylpenicillin.肠道细菌的耐药性。十四。对α-氨基苄青霉素耐药的革兰氏阴性杆菌中β-内酰胺酶的比较。
Jpn J Microbiol. 1968 Dec;12(4):423-34. doi: 10.1111/j.1348-0421.1968.tb00415.x.
6
Effects of beta-lactamase from gram-negative organisms on cephalosporins and penicillins.革兰氏阴性菌产生的β-内酰胺酶对头孢菌素和青霉素的影响。
Antimicrob Agents Chemother (Bethesda). 1968;8:57-63.
7
Inducible beta-lactamase in Enterobacter.肠杆菌中的诱导型β-内酰胺酶
J Gen Microbiol. 1967 Nov;49(2):277-85. doi: 10.1099/00221287-49-2-277.
8
The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli.大肠杆菌中由可传递R因子介导的青霉素β-内酰胺酶的纯化及特性
J Biochem. 1969 Jul;66(1):11-20. doi: 10.1093/oxfordjournals.jbchem.a129111.

产气克雷伯菌1082E和阴沟肠杆菌P99的β-内酰胺酶底物特异性比较。

Comparison of the substrate specificities of the -lactamases from Klebsiella aerogenes 1082E and Enterobacter cloacae P99.

作者信息

Marshall M J, Ross G W, Chanter K V, Harris A M

出版信息

Appl Microbiol. 1972 Apr;23(4):765-9. doi: 10.1128/am.23.4.765-769.1972.

DOI:10.1128/am.23.4.765-769.1972
PMID:4553144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC380432/
Abstract

A potent beta-lactamase (EC 3.5.2.6) produced by a strain of Klebsiella aerogenes (K. pneumoniae), 1082E, isolated from a hospital patient, has been examined. Its properties were different from those of most gram-negative beta-lactamases previously reported. The enzyme has been partly purified, and its activity against a range of substrates has been compared with that of the enzyme from Enterobacter cloacae (Aerobacter cloacae) P99. The K. aerogenes enzyme, although predominantly a penicillinase, had a wide range of specificity. In addition to hydrolyzing the cephalosporins, it attacked the normally beta-lactamaseresistant compounds methicillin and cloxacillin as well as cephalosporin analogues with the same acyl substituents. The results obtained with the E. cloacae enzyme confirmed its cephalosporinase activity and showed that, unlike the enzyme from K. aerogenes, it was relatively inactive against the penicillins.

摘要

对从一名医院患者身上分离出的产气克雷伯菌（肺炎克雷伯菌）1082E菌株产生的一种强效β-内酰胺酶（EC 3.5.2.6）进行了研究。其特性与先前报道的大多数革兰氏阴性β-内酰胺酶不同。该酶已部分纯化，并且已将其对一系列底物的活性与阴沟肠杆菌（产气气杆菌）P99产生的酶的活性进行了比较。产气克雷伯菌酶虽然主要是一种青霉素酶，但具有广泛的特异性。除了水解头孢菌素外，它还能攻击通常对β-内酰胺酶耐药的化合物甲氧西林和氯唑西林以及具有相同酰基取代基的头孢菌素类似物。用阴沟肠杆菌酶获得的结果证实了其头孢菌素酶活性，并表明，与产气克雷伯菌产生的酶不同，它对青霉素的活性相对较低。