革兰氏阴性菌中R因子与染色体β-内酰胺酶之间的一些关系。
Some relationships between R-factor and chromosomal -lactamase in Gram-negative bacteria.
作者信息
Dale J W, Smith J T
出版信息
Biochem J. 1971 Jul;123(4):507-12. doi: 10.1042/bj1230507.
Abstract
- The beta-lactamases specified by Klebsiella aerogenes 418 and the R-factor R-7268 have been partially purified. 2. The molecular weights of the K. aerogenes strains 418 and 373, Aerobacter cloacae 53, R-7268 and R-TEM beta-lactamases were all about 20000; that of the enzymes from Escherichia coli strains 419 and 214T was about 31000. 3. These enzymes were also compared by means of their K(m) values for benzylpenicillin and ampicillin, and their behaviour on starch-gel electrophoresis. 4. The beta-lactamases specified by the two Klebsiella strains, the Aerobacter strain, and the R-factors R-TEM and R-7268 were found to comprise a broadly similar group. However, within this group, only two enzymes seemed to be identical, namely those specified by the two R-factors. The two E. coli strains produce identical beta-lactamases which are very different from the ;Klebsiella/Aerobacter-type' enzymes.
摘要
- 产气克雷伯菌418和R因子R - 7268所产生的β - 内酰胺酶已被部分纯化。2. 产气克雷伯菌菌株418和373、阴沟肠杆菌53、R - 7268和R - TEMβ - 内酰胺酶的分子量均约为20000；大肠杆菌菌株419和214T的酶分子量约为31000。3. 还通过这些酶对苄青霉素和氨苄青霉素的米氏常数（K(m)值）以及它们在淀粉凝胶电泳中的行为对这些酶进行了比较。4. 发现两种克雷伯菌菌株、阴沟肠杆菌菌株以及R因子R - TEM和R - 7268所产生的β - 内酰胺酶构成了一个大致相似的组。然而，在这个组内，似乎只有两种酶是相同的，即由两个R因子所产生的酶。两种大肠杆菌菌株产生相同的β - 内酰胺酶，这些酶与“克雷伯菌/肠杆菌型”酶非常不同。
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