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酿酒酵母中核黄素的生物合成：rib 1和rib 7基因的作用

Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 .

作者信息

Oltmanns O, Bacher A

出版信息

J Bacteriol. 1972 Jun;110(3):818-22. doi: 10.1128/jb.110.3.818-822.1972.

DOI:10.1128/jb.110.3.818-822.1972
PMID:4555411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC247498/
Abstract

Haploid strains of Saccharomyces cerevisiae with mutations in two different rib genes were constructed. These strains were studied by tetrad analysis and by quantitative determination of accumulation products. The genes rib(1), rib(7), and rib(2) are not linked to each other. rib(1)-rib(7) strains and rib(1)-rib(2) strains exhibit the phenotypic properties of rib(1) strains. rib(7)-rib(2) strains show the phenotypic properties of rib(7) strains. The results support the conclusion that the genes rib(1) and rib(7) code for the first and second enzyme of the riboflavine pathway, respectively.

摘要

构建了在两个不同核糖体基因中发生突变的酿酒酵母单倍体菌株。通过四分体分析和对积累产物的定量测定对这些菌株进行了研究。核糖体基因rib(1)、rib(7)和rib(2)彼此不连锁。rib(1)-rib(7)菌株和rib(1)-rib(2)菌株表现出rib(1)菌株的表型特性。rib(7)-rib(2)菌株表现出rib(7)菌株的表型特性。这些结果支持了核糖体基因rib(1)和rib(7)分别编码核黄素途径的第一种和第二种酶的结论。

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Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 .酿酒酵母中核黄素的生物合成：rib 1和rib 7基因的作用
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本文引用的文献

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The Detection of Linkage in Tetrad Analysis.四分子分析中的连锁检测
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Application of chromatography. XXXII. Biosynthesis of riboflavin by Eremothecium ashbyii.色谱法的应用。第三十二篇。阿舒假囊酵母合成核黄素的生物合成。
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Biosynthesis of riboflavin. Formation of 2,5-diamino-6-hydroxy-4-(1'-D-ribitylamino)pyrimidine in a riboflavin auxotroph.核黄素的生物合成。核黄素营养缺陷型中2,5-二氨基-6-羟基-4-(1'-D-核糖基氨基)嘧啶的形成。
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Stereospecificity of the enzymatic synthesis of the o-xylene ring of riboflavin.核黄素邻二甲苯环酶促合成的立体特异性
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Studies on the mechanism of elimination of protons from the methyl groups of 6,7-dimethyl-8-ribityllumazine by riboflavin synthetase.关于核黄素合成酶从6,7 - 二甲基 - 8 - 核糖基卢马嗪的甲基中消除质子机制的研究。
Biochemistry. 1970 Feb 17;9(4):771-85. doi: 10.1021/bi00806a010.
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Biochemical and genetic classification of riboflavine deficient mutants of Saccharomyces cerevisiae.酿酒酵母核黄素缺陷型突变体的生化与遗传分类
Mol Gen Genet. 1969;105(4):306-13. doi: 10.1007/BF00277585.
9
Biosynthesis of riboflavin. Formation of 6-hydroxy-2,4,5-triaminopyrimidine in rib 7 mutants of Saccharomyces cerevisiae.核黄素的生物合成。酿酒酵母rib 7突变体中6-羟基-2,4,5-三氨基嘧啶的形成。
J Biol Chem. 1971 Nov 25;246(22):7018-22.
10
[On intermediates of riboflavin biosynthesis in Saccharomyces cerevisiae].
Z Naturforsch B. 1967 Jul;22(7):755-8.