阿司匹林与贝诺酯治疗类风湿关节炎的比较。
Comparison of aspirin and benorylate in the treatment of rheumatoid arthritis.
作者信息
Beales D L, Burry H C, Grahame R
出版信息
Br Med J. 1972 May 27;2(5812):483-5. doi: 10.1136/bmj.2.5812.483.
Abstract
In a double-blind between-patient study of aspirin and benorylate carried out in 72 outpatients with rheumatoid arthritis, benorylate 4 g twice daily was shown to be an effective analgesic and anti-inflammatory drug, its effects being indistinguishable from those of aspirin 1.2 g four times daily. Compared with the pretreatment values both drugs produced a statistically significant improvement (P < 0.01) in functional grade, overall pain, articular index, and grip strength at the end of the first and second weeks. The overall incidence of side effects was less with benorylate, though this difference was not significant at the 5% level.
摘要
在一项针对72名类风湿性关节炎门诊患者进行的阿司匹林与贝诺酯的双盲、患者间对照研究中，每日两次服用4克贝诺酯被证明是一种有效的止痛和抗炎药物，其效果与每日四次服用1.2克阿司匹林的效果无明显差异。与治疗前的值相比，两种药物在第一周和第二周结束时在功能分级、总体疼痛、关节指数和握力方面均产生了具有统计学意义的改善（P < 0.01）。贝诺酯的副作用总发生率较低，尽管在5%的水平上这种差异并不显著。
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