酮洛芬与布洛芬治疗类风湿性关节炎的双盲交叉研究
Double-blind cross-over study of ketoprofen and ibuprofen in management of rheumatoid arthritis.
作者信息
Mills S B, Bloch M, Bruckner F E
出版信息
Br Med J. 1973 Oct 13;4(5884):82-4. doi: 10.1136/bmj.4.5884.82.
Abstract
A double-blind cross-over study of ketoprofen (Orudis) 150 mg daily and ibuprofen (Brufen) 1,200 mg daily was carried out in 35 outpatients with rheumatoid arthritis. Results suggest that analgesic and anti-inflammatory activity of ketoprofen is superior to that of ibuprofen. Significantly greater pain relief (P < 0.05) and reduction in joint circumference (P < 0.01) was obtained with ketoprofen than with ibuprofen. Side effects of the drugs were comparable and not serious.
摘要
对35名类风湿性关节炎门诊患者进行了一项双盲交叉研究，比较每日服用150毫克酮洛芬（奥鲁地）和每日服用1200毫克布洛芬（布洛芬）的效果。结果表明，酮洛芬的镇痛和抗炎活性优于布洛芬。与布洛芬相比，酮洛芬能显著减轻疼痛（P < 0.05）并减小关节周长（P < 0.01）。两种药物的副作用相当，且不严重。
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本文引用的文献
1
THE FEET OF CLAY OF THE DOUBLE-BLIND TRIAL.双盲试验的致命弱点
Lancet. 1963 Nov 9;2(7315):994-7. doi: 10.1016/s0140-6736(63)90693-7.
2
DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.类风湿关节炎的诊断标准：美国风湿病协会委员会1958年修订版。
Ann Rheum Dis. 1959 Mar;18(1):49-51; French transl 51-2; Spanish transl 52-3.
3
The long-term benefits of ibuprofen in rheumatological practice. Interim report.布洛芬在风湿病治疗中的长期益处。中期报告。
Practitioner. 1971 Sep;207(239):343-8.
4
Double-blind cross-over study of Orudis and placebo in fifty patients with rheumatoid arthritis.奥鲁地（Orudis）与安慰剂治疗五十例类风湿性关节炎患者的双盲交叉研究。
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5
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