Blasingham M C, Selkurt E E
Circ Shock. 1979;6(1):31-42.
The influence of intravenously administered PGE1 on renal function in standardized hemorrhagic shock in dogs was examined in this study. Infusion rates as high as 1.04 micrograms/min/kg were evaluated. Although arterial blood levels as high as 2.47 ng/ml of plasma compared to control values of less than 0.20 ng/ml were attained during postreinfusion treatment, no beneficial influences on renal functional parameters (hemodynamics, electrolyte and water handling) were observed. In fact, treated animals took up blood from the arterial reservoir more quickly and expired sooner following blood transfusion than an untreated series. A further deleterious change in renal function was a decrease in renal concentrating capability. It is concluded that with the severe grade of hemorrhagic shock employed in these studies, organ blood perfusion was restricted to the extent of limiting effective PGE action.
本研究检测了静脉注射前列腺素E1（PGE1）对犬标准化失血性休克肾功能的影响。评估了高达1.04微克/分钟/千克的输注速率。尽管在再输注治疗期间，血浆动脉血水平高达2.47纳克/毫升，而对照值低于0.20纳克/毫升，但未观察到对肾功能参数（血液动力学、电解质和水代谢）有有益影响。事实上，与未治疗组相比，治疗组动物在输血后从动脉贮血库摄取血液更快，死亡更早。肾功能的另一个有害变化是肾脏浓缩能力下降。结论是，在这些研究中采用的严重失血性休克程度下，器官血液灌注受限，限制了PGE的有效作用。
