Haglund U, Lundgren O
Circ Shock. 1979;6(1):89-97.
Regional intestinal hypotension (arterial inflow pressure about 30 mmHg) was induced in cats by partially occluding the superior mesenteric artery with an adjustable clamp. The superior mesenteric vein was cannulated and the intestinal venous outflow recorded by a drop counter. The intestinal venous blood bypassed in one series the liver and was returned to the animal via the jugular vein. In two other series it was returned via the portal vein and in one of these also the hepatic arterial pressure was kept at 30 mmHg. Following two hours of regional intestinal shock a general cardiovascular derangement was evident in all series. This was not influenced by directing the intestinal venous blood flow through a normotensive or hypotensive liver. Characteristic intestinal mucosal lesions were found in all series. It is concluded that bypassing or directing the intestinal venous blood through a normotensive or hypotensive liver did not affect the local and general cardiovascular effects of regional intestinal hypotension.
通过使用可调节夹部分阻断肠系膜上动脉，在猫身上诱发区域性肠道低血压（动脉流入压约为30 mmHg）。将肠系膜上静脉插管，并通过滴数计数器记录肠道静脉流出量。在一组实验中，肠道静脉血绕过肝脏，经颈静脉回流至动物体内。在另外两组实验中，肠道静脉血经门静脉回流，其中一组还将肝动脉压维持在30 mmHg。在区域性肠道休克两小时后，所有组均出现明显的全身心血管紊乱。这不受肠道静脉血流经正常血压或低血压肝脏的影响。所有组均发现了典型的肠道黏膜病变。得出的结论是，肠道静脉血绕过肝脏或经正常血压或低血压肝脏引流，均不影响区域性肠道低血压对局部和全身心血管的影响。
