Falk A, Kaijser B, Myrvold H E, Haglund U
Circ Shock. 1980;7(3):239-50.
Septic shock was induced in cats by i.v. infusion of live E. coli bacteria. The reactions of the series-coupled sections of the small intestinal vascular bed were followed continuously by a plethysmographic technique. Intestinal venous outflow was recorded using a drop counting technique. Intestinal venous outflow was recorded using a drop counting technique. The chest was opened and blood flow in the ascending aorta was followed electromagnetically. Pulmonary arterial blood pressure was recorded after direct cannulation. Following infusion of washed E. coli bacteria suspended in saline, a rapid early response was evident. This was characterized by arterial hypotension, unchanged aortic blood flow, pulmonary hypertension, and intestinal vasoconstriction. After 5-10 min a period of relative normalization followed. After 30-60 min a second phase, characterized by general circulatory deterioration, developed. The induced septic shock was initially characterized by a slight intestinal vasoconstriction. There was no accumulation of blood or fluid in the intestinal vascular bed; an isovolumetric state was thereby maintained in intestinal tissue throughout the experiments.
通过静脉输注活的大肠杆菌在猫身上诱发脓毒症休克。采用体积描记技术连续跟踪小肠血管床串联节段的反应。使用滴数计数技术记录肠静脉流出量。打开胸腔，用电磁法跟踪升主动脉中的血流。直接插管后记录肺动脉血压。输注悬浮于盐水中的洗涤过的大肠杆菌后，早期快速反应明显。其特征为动脉低血压、主动脉血流不变、肺动脉高压和肠血管收缩。5 - 10分钟后出现一段相对正常化时期。30 - 60分钟后进入第二阶段，其特征为全身循环恶化。诱发的脓毒症休克最初的特征是肠血管略有收缩。肠血管床中没有血液或液体蓄积；因此在整个实验过程中肠道组织保持等容状态。
