Muskiet F A, Groen A
Clin Chem. 1979 Jul;25(7):1281-4.
We report quantitative data on beta-glucuronidase- and sulfatase-hydrolyzable conjugates of homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid in the urine of 20 apparently normal and healthy control persons and of three patients with neuroblastoma. We used organic solvent extraction and capillary gas chromatography. There was considerable person-to-person variation in the conjugation percentages calculated. Mean conjugated percentages of the four compounds for 16 normal healthy persons 2.5--40 years of age were, respectively, 12%, 33%, 14%, and 35%. For newborns and patients with neuroblastoma, these percentages were somewhat different. Increased amounts of vanillic acid were found in the urine of the patients with neuroblastoma, but results of a small metabolic study in rats suggest that this increase most probably is of dietary origin.
我们报告了20名表面上正常且健康的对照者以及3名神经母细胞瘤患者尿液中高香草酸、3,4 - 二羟基苯乙酸、对羟基苯乙酸和香草酸的β - 葡萄糖醛酸酶和硫酸酯酶可水解共轭物的定量数据。我们采用了有机溶剂萃取和毛细管气相色谱法。计算出的共轭百分比存在相当大的个体差异。16名年龄在2.5至40岁的正常健康人的这四种化合物的平均共轭百分比分别为12%、33%、14%和35%。对于新生儿和神经母细胞瘤患者，这些百分比有所不同。在神经母细胞瘤患者的尿液中发现香草酸含量增加，但在大鼠身上进行的一项小型代谢研究结果表明，这种增加很可能源于饮食。
