Hande K R, Perini F, Putterman G, Elin R
Clin Chem. 1979 Aug;25(8):1492-4.
Serum xanthine concentrations as high as 148 mg/L were noted after treatment of a patient with Burkitt's lymphoma who was receiving allopurinol. These markedly above-normal values for xanthine led to spuriously low values for serum uric acid as measured by the uricase method. Rapid tumor lysis in patients who are receiving allopurinol may lead to marked hyperxanthinemia, which in turn may obscure hyperuricemia in such patients when the uricase method is used for uric acid analysis. In such situations, uric acid concentrations should be measured by the phosphotungstate colorimetric assay.
在一名接受别嘌呤醇治疗的伯基特淋巴瘤患者治疗后，发现血清黄嘌呤浓度高达148毫克/升。这些明显高于正常水平的黄嘌呤值导致用尿酸酶法测得的血清尿酸值假性降低。接受别嘌呤醇治疗的患者肿瘤快速溶解可能导致明显的高黄嘌呤血症，而当使用尿酸酶法进行尿酸分析时，这反过来可能掩盖此类患者的高尿酸血症。在这种情况下，应采用磷钨酸比色法测定尿酸浓度。
